Document Detail


Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
MedLine Citation:
PMID:  20608755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is a large body of evidence to suggest that improving periconceptional folate status reduces the risk of neonatal neural tube defects. Thus increased folate intake is now recommended before and during the early stages of pregnancy, through folic acid supplements or fortified foods. Furthermore, there is growing evidence that folic acid may have a role in the prevention of other diseases, including dementia and certain types of cancer. Folic acid is a synthetic form of the vitamin, which is only found in fortified foods, supplements and pharmaceuticals. It lacks coenzyme activity and must be reduced to the metabolically active tetrahydrofolate form within the cell. L-5-methyl-tetrahydrofolate (L-5-methyl-THF) is the predominant form of dietary folate and the only species normally found in the circulation, and hence it is the folate that is normally transported into peripheral tissues to be used for cellular metabolism. L-5-methyl-THF is also available commercially as a crystalline form of the calcium salt (Metafolin(R)), which has the stability required for use as a supplement. Studies comparing L-5-methyl-THF and folic acid have found that the two compounds have comparable physiological activity, bioavailability and absorption at equimolar doses. Bioavailability studies have provided strong evidence that L-5-methyl-THF is at least as effective as folic acid in improving folate status, as measured by blood concentrations of folate and by functional indicators of folate status, such as plasma homocysteine. Intake of L-5-methyl-THF may have advantages over intake of folic acid. First, the potential for masking the haematological symptoms of vitamin B(12) deficiency may be reduced with L-5-methyl-THF. Second, L-5-methyl-THF may be associated with a reduced interaction with drugs that inhibit dihydrofolate reductase.
Authors:
Klaus Pietrzik; Lynn Bailey; Barry Shane
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  49     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-05     Revised Date:  2012-02-29    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  535-48     Citation Subset:  IM    
Affiliation:
Institute of Nutrition and Food Sciences, University of Bonn, Bonn, Germany. k.pietrzik@uni-bonn.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Biological Availability
Drug Interactions
Female
Folic Acid / adverse effects,  metabolism,  pharmacokinetics*,  pharmacology*
Folic Acid Antagonists / pharmacology
Humans
Intestinal Absorption
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Middle Aged
Pregnancy
Tetrahydrofolate Dehydrogenase / metabolism
Tetrahydrofolates / adverse effects,  metabolism,  pharmacokinetics*,  pharmacology*
Young Adult
Chemical
Reg. No./Substance:
0/Folic Acid Antagonists; 0/Tetrahydrofolates; 134-35-0/5-methyltetrahydrofolate; 59-30-3/Folic Acid; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 1.5.1.3/Tetrahydrofolate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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