| Folic Acid Consumption throughout Pregnancy - Differentiation between Trimesters. | |
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MedLine Citation:
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PMID: 22123638 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Intervention trials have demonstrated conclusively that oral ingestion of extra folic acid can prevent the majority of cases of spina bifida and other neural tube defects (NTDs). Data from these studies offer conclusive evidence that the intake of 400 μg/day folic acid provides this benefit. The big problem has remained that the neural plate closes to form the neural tube between day 21 and day 28 postconception, at which point most women do not even realize that they are pregnant. This, coupled with the fact that over half of all pregnancies are unplanned, has resulted in many studies showing that less than one-fifth of pregnancies have followed the recommendation for prevention. However, where compliance has been good or where folic acid has been added mandatorily, there has been the expected reduction in NTDs. Clarity regarding what is recommended for early pregnancy does not carry through to the second or third trimester of pregnancy where practices vary widely not only from country to country but even from clinician to clinician within particular countries. |
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Authors:
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John Scott |
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Publication Detail:
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Type: Journal Article Date: 2011-11-25 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 59 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 46-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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