| Folic Acid Conjugated Amino Acid-Based Star Polymers for Active Targeting of Cancer Cells. | |
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MedLine Citation:
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PMID: 21854075 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Amino acid-based core cross-linked star (CCS) polymers (poly(L-lysine)armpoly(L-cystine)core) with peripheral allyl functionalities were synthesized by sequential ring opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs) via the arm-first approach, using N-(trimethylsilyl)allylamine as the initiator. Subsequent functionalization with a poly(ethylene glycol) (PEG)-folic acid conjugate via thiol-ene click chemistry afforded poly(PEG-b-L-lysine)armpoly(L-cystine)core stars with outer PEG coronas decorated with folic acid targeting moieties. Similarly, a control was prepared without folic acid, using just PEG. A fluorophore was used to track both star polymers incubated with breast cancer cells (MDA-MB-231) in vitro. Confocal microscopy and flow cytometry revealed that the stars could be internalized into the cells and higher cell internalization was observed when folic acid moieties were present. Cytotoxicity studies indicate that both stars are non-toxic to MDA-MB-231 cells at concentrations of up to 100 μg/mL. These make this amino acid-based star polymer an attractive candidate in targeted drug delivery applications including chemotherapy. |
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Authors:
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Adrian Sulistio; Justin Lowenthal; Anton Blencowe; Marie Louise Bongiovanni; Lydia Ong; Sally Louise Gras; Xiaoqing Zhang; Greg Guanghua Qiao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-22 |
Journal Detail:
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Title: Biomacromolecules Volume: - ISSN: 1526-4602 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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