| Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. | |
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MedLine Citation:
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PMID: 11509098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet known to be deficient in vitamin B12. In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered. In this review, is described the metabolism of and interrelations between folate, vitamin B12 and homocysteine. This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome. |
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Authors:
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H Refsum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The British journal of nutrition Volume: 85 Suppl 2 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-08-17 Completed Date: 2001-08-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: S109-13 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway. helga.refsum@farm.uib.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Abnormalities
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etiology,
prevention & control Deficiency Diseases / metabolism*, prevention & control Developing Countries* Female Folic Acid / administration & dosage, metabolism* Folic Acid Deficiency / complications, drug therapy Homocysteine / metabolism* Humans Infant, Newborn Neural Tube Defects / etiology Pregnancy Pregnancy Complications / metabolism*, prevention & control Pregnancy Outcome Vitamin B 12 / administration & dosage, metabolism* Vitamin B 12 Deficiency / complications, drug therapy |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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