Document Detail

Folate transport by the choroid plexus in vitro.
MedLine Citation:
PMID:  1167256     Owner:  NLM     Status:  MEDLINE    
Reduced folates are transported from blood into cerebrospinal fluid against a concentration gradient. In vitro, folates were transported into and released by isolated rabbit choroid plexuses. The choroid plexus uptake mechanism was specific for folates, energy dependent, and depressed by cold temperatures. In vivo, the choroid plexus may transport folates from blood to cerebrospinal fluid.
R Spector; A V Lorenzo
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  187     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-13     Completed Date:  1975-05-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-2     Citation Subset:  IM    
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MeSH Terms
Blood-Brain Barrier
Choroid Plexus / metabolism*
Cold Temperature
Folic Acid / blood,  metabolism*
Tetrahydrofolates / metabolism
Reg. No./Substance:
0/Tetrahydrofolates; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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