Document Detail

Folate supplementation and twinning in patients with sickle cell disease.
MedLine Citation:
PMID:  16550509     Owner:  NLM     Status:  MEDLINE    
Patients with sickle cell disease routinely take folic acid daily as a supplement to maintain effective erythropoiesis. One of the controversial effects of folic acid is its effect on twin gestation rates. In this report, we present our experience in patients with sickle cell disease and twin pregnancy. Our data show that twin pregnancies seem to be associated with folate supplementation.
Samir K Ballas; Jason K Baxter; Gaye Riddick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  81     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-27     Completed Date:  2006-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-7     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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MeSH Terms
Abortion, Spontaneous / epidemiology,  etiology*
Anemia, Sickle Cell* / complications,  diet therapy
Erythropoiesis / drug effects
Fetal Death / etiology
Folic Acid / administration & dosage*,  adverse effects
Hematinics / administration & dosage*,  adverse effects
Parity* / drug effects
Twinning, Monozygotic* / drug effects
Vitamin B 12 Deficiency / etiology
Reg. No./Substance:
0/Hematinics; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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