| Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways. | |
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MedLine Citation:
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PMID: 15800896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Supplementation of a pregnant mother's diet with folate has been shown to protect the developing embryo from birth defects in humans as well as rodent animal models. Folate supplementation not only reverses a potential nutritional deficiency; folate effectively prevents defects even when the mother's nutritional status is normal. These findings indicate that folate is able to interact with the molecular pathways that control normal embryonic development. Supplementation studies in animals provide the experimental starting point for the identification of such folate-responsive pathways. This review summarizes the progress to date in understanding the folate response in genetic models of birth defects in the mouse. |
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Authors:
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Claudia Kappen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: American journal of medical genetics. Part C, Seminars in medical genetics Volume: 135C ISSN: 1552-4868 ISO Abbreviation: - Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-25 Completed Date: 2005-07-26 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 101235745 Medline TA: Am J Med Genet C Semin Med Genet Country: United States |
Other Details:
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Languages: eng Pagination: 24-30 Citation Subset: IM |
Copyright Information:
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Copyright 2005 Wiley-Liss, Inc |
Affiliation:
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Department of Genetics, Cell Biology and Anatomy, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha 68198-5455, USA. ckppen@unmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Congenital Abnormalities / genetics, prevention & control* Dietary Supplements Disease Models, Animal Female Folic Acid / therapeutic use* Gene Expression Regulation, Developmental / drug effects* Humans Mice Models, Genetic Pregnancy |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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