Document Detail


Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways.
MedLine Citation:
PMID:  15800896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Supplementation of a pregnant mother's diet with folate has been shown to protect the developing embryo from birth defects in humans as well as rodent animal models. Folate supplementation not only reverses a potential nutritional deficiency; folate effectively prevents defects even when the mother's nutritional status is normal. These findings indicate that folate is able to interact with the molecular pathways that control normal embryonic development. Supplementation studies in animals provide the experimental starting point for the identification of such folate-responsive pathways. This review summarizes the progress to date in understanding the folate response in genetic models of birth defects in the mouse.
Authors:
Claudia Kappen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  American journal of medical genetics. Part C, Seminars in medical genetics     Volume:  135C     ISSN:  1552-4868     ISO Abbreviation:  Am J Med Genet C Semin Med Genet     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-07-26     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  101235745     Medline TA:  Am J Med Genet C Semin Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-30     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc
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MeSH Terms
Descriptor/Qualifier:
Animals
Congenital Abnormalities / genetics,  prevention & control*
Dietary Supplements
Disease Models, Animal
Female
Folic Acid / therapeutic use*
Gene Expression Regulation, Developmental / drug effects*
Humans
Mice
Models, Genetic
Pregnancy
Grant Support
ID/Acronym/Agency:
P20 RR018788/RR/NCRR NIH HHS; R01 HD037804/HD/NICHD NIH HHS; R01 HD037804-04/HD/NICHD NIH HHS; R21 DE014523/DE/NIDCR NIH HHS; R21 DE014523-02/DE/NIDCR NIH HHS; R21 HD048516/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
935E97BOY8/Folic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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