| Folate supplementation during methotrexate therapy for rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 21044441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methotrexate (MTX), an antifolate, is an anchor drug for the treatment of rheumatoid arthritis (RA). Both folic acid (FA) and folinic acid (FLN) supplements have been shown to reduce the toxicity of MTX when used in RA therapy. The effect of folate supplementation on MTX efficacy still needs to be studied. FA supplementation has been found to have a beneficial effect on homocysteine (hcy) metabolism and may prevent the formation of the less effective metabolite 7-hydroxy-MTX. The cost of FA supplements is substantially less than the cost of FLN supplements. This article reviews clinical trials related to folate supplementation during MTX therapy for RA. |
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Authors:
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S L Morgan; J E Baggott |
Publication Detail:
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Type: Journal Article; Review Date: 2010-10-28 |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 28 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: S102-9 Citation Subset: IM |
Affiliation:
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Schools of Health Professions, Medicine, and Dentistry, Birmingham, AL 35294-1270, USA. slmorgan@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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adverse effects,
therapeutic use* Arthritis, Rheumatoid / drug therapy* Clinical Trials as Topic Dietary Supplements* Evidence-Based Medicine Folic Acid / therapeutic use* Humans Leucovorin / therapeutic use Methotrexate / adverse effects, therapeutic use* Practice Guidelines as Topic Treatment Outcome Vitamin B Complex / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 12001-76-2/Vitamin B Complex; 58-05-9/Leucovorin; 59-05-2/Methotrexate; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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