Document Detail

Folate supplementation during methotrexate therapy for rheumatoid arthritis.
MedLine Citation:
PMID:  21044441     Owner:  NLM     Status:  MEDLINE    
Methotrexate (MTX), an antifolate, is an anchor drug for the treatment of rheumatoid arthritis (RA). Both folic acid (FA) and folinic acid (FLN) supplements have been shown to reduce the toxicity of MTX when used in RA therapy. The effect of folate supplementation on MTX efficacy still needs to be studied. FA supplementation has been found to have a beneficial effect on homocysteine (hcy) metabolism and may prevent the formation of the less effective metabolite 7-hydroxy-MTX. The cost of FA supplements is substantially less than the cost of FLN supplements. This article reviews clinical trials related to folate supplementation during MTX therapy for RA.
S L Morgan; J E Baggott
Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-28
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  28     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S102-9     Citation Subset:  IM    
Schools of Health Professions, Medicine, and Dentistry, Birmingham, AL 35294-1270, USA.
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MeSH Terms
Antirheumatic Agents / adverse effects,  therapeutic use*
Arthritis, Rheumatoid / drug therapy*
Clinical Trials as Topic
Dietary Supplements*
Evidence-Based Medicine
Folic Acid / therapeutic use*
Leucovorin / therapeutic use
Methotrexate / adverse effects,  therapeutic use*
Practice Guidelines as Topic
Treatment Outcome
Vitamin B Complex / therapeutic use*
Reg. No./Substance:
0/Antirheumatic Agents; 12001-76-2/Vitamin B Complex; 58-05-9/Leucovorin; 59-05-2/Methotrexate; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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