Document Detail

Folate requirement and metabolism in nonpregnant women.
MedLine Citation:
PMID:  3687819     Owner:  NLM     Status:  MEDLINE    
Folate metabolism and requirements were studied in 10 adult nonpregnant women maintained for 92 d in a metabolic unit. After a folate depletion period of 28 d, the subjects received increasing supplements of folate from food items or as pteroylmonoglutamic acid (PGA). Plasma folate levels fell 60% during the depletion period and continued to fall until 200 micrograms/d of naturally occurring food folates were provided. Supplements of 300 micrograms/d of naturally occurring folates produced a small rise in plasma folate levels although erythrocyte folate levels continued to fall. Lymphocyte deoxyuridine suppression, neutrophil hypersegmentation, and other measurements related to folate metabolism were performed. When compared with PGA, dietary folates appeared to be no more than 50% available. A daily intake of 200-250 micrograms of dietary folates appears to meet the folate requirements of nonpregnant adult women whereas an intake of 300 micrograms/d provides an allowance for storage.
H E Sauberlich; M J Kretsch; J H Skala; H L Johnson; P C Taylor
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  46     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-19     Completed Date:  1988-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1016-28     Citation Subset:  AIM; IM    
USDA-Western Human Nutrition Research Center, Presidio of San Francisco, CA.
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MeSH Terms
Deoxyuridine / metabolism
Folic Acid / administration & dosage*,  metabolism
Hemoglobins / analysis
Lymphocytes / metabolism
Neutrophils / ultrastructure
Nutritional Requirements
Grant Support
Reg. No./Substance:
0/Hemoglobins; 59-30-3/Folic Acid; 951-78-0/Deoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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