| Folate requirement and metabolism in nonpregnant women. | |
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MedLine Citation:
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PMID: 3687819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate metabolism and requirements were studied in 10 adult nonpregnant women maintained for 92 d in a metabolic unit. After a folate depletion period of 28 d, the subjects received increasing supplements of folate from food items or as pteroylmonoglutamic acid (PGA). Plasma folate levels fell 60% during the depletion period and continued to fall until 200 micrograms/d of naturally occurring food folates were provided. Supplements of 300 micrograms/d of naturally occurring folates produced a small rise in plasma folate levels although erythrocyte folate levels continued to fall. Lymphocyte deoxyuridine suppression, neutrophil hypersegmentation, and other measurements related to folate metabolism were performed. When compared with PGA, dietary folates appeared to be no more than 50% available. A daily intake of 200-250 micrograms of dietary folates appears to meet the folate requirements of nonpregnant adult women whereas an intake of 300 micrograms/d provides an allowance for storage. |
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Authors:
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H E Sauberlich; M J Kretsch; J H Skala; H L Johnson; P C Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 46 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-01-19 Completed Date: 1988-01-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1016-28 Citation Subset: AIM; IM |
Affiliation:
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USDA-Western Human Nutrition Research Center, Presidio of San Francisco, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Deoxyuridine / metabolism Diet FIGLU Test Folic Acid / administration & dosage*, metabolism Hematocrit Hemoglobins / analysis Humans Lymphocytes / metabolism Male Neutrophils / ultrastructure Nutritional Requirements |
| Grant Support | |
ID/Acronym/Agency:
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5 PO1-CA28103/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 59-30-3/Folic Acid; 951-78-0/Deoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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