| Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability. | |
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MedLine Citation:
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PMID: 20137055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review summarizes current knowledge of the effect of folate-mediated one-carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with lower ovarian reserves, diminished response to follicular stimulation, and reduced chance of live birth after in vitro fertilization. Embryos carrying multiple MTHFR variants appear to have a selective disadvantage; however, the heterozygous MTHFR 677CT genotype in the mother and fetus provides the greatest chance for a viable pregnancy and live birth, possibly due to a favorable balance in folate cofactor distribution between methyl donor and nucleotide synthesis. The results of previous studies clearly emphasize that imbalances in folate metabolism and related gene variants may impair female fecundity as well as compromise implantation and the chance of a live birth. |
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Authors:
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Margit Laanpere; Signe Altm?e; Anneli Stavreus-Evers; Torbj?rn K Nilsson; Agneta Yngve; Andres Salumets |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 68 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 99-113 Citation Subset: IM |
Affiliation:
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Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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DNA Methylation
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drug effects Female Fertility / drug effects* Fetal Development / drug effects Folic Acid / metabolism*, pharmacology Folic Acid Deficiency / complications Genetic Variation* Homocysteine / blood Humans Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Pregnancy Pregnancy Maintenance / drug effects Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; 59-30-3/Folic Acid; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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