Document Detail

Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability.
MedLine Citation:
PMID:  20137055     Owner:  NLM     Status:  MEDLINE    
This review summarizes current knowledge of the effect of folate-mediated one-carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with lower ovarian reserves, diminished response to follicular stimulation, and reduced chance of live birth after in vitro fertilization. Embryos carrying multiple MTHFR variants appear to have a selective disadvantage; however, the heterozygous MTHFR 677CT genotype in the mother and fetus provides the greatest chance for a viable pregnancy and live birth, possibly due to a favorable balance in folate cofactor distribution between methyl donor and nucleotide synthesis. The results of previous studies clearly emphasize that imbalances in folate metabolism and related gene variants may impair female fecundity as well as compromise implantation and the chance of a live birth.
Margit Laanpere; Signe Altm?e; Anneli Stavreus-Evers; Torbj?rn K Nilsson; Agneta Yngve; Andres Salumets
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  68     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-113     Citation Subset:  IM    
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
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MeSH Terms
DNA Methylation / drug effects
Fertility / drug effects*
Fetal Development / drug effects
Folic Acid / metabolism*,  pharmacology
Folic Acid Deficiency / complications
Genetic Variation*
Homocysteine / blood
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Pregnancy Maintenance / drug effects
Pregnancy Outcome
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; EC Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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