| Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. | |
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MedLine Citation:
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PMID: 22292644 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: Genetic and environmental factors may play roles in the pathogenesis of esophageal cancer and susceptibility may be modified by functional polymorphisms in folate metabolic genes, such as methylenetetrahydrofolate reductase (MTHFR). We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer. Methods: A matched hospital-based case-control study with 155 esophageal cancer and 310 non-cancer controls was conducted in Southern of China with gene-environment interactions evaluated between the MTHFR C667T polymorphism and drinking and smoking, as well as folate intake. Results: Individuals carrying MTHFR 667CT [adjusted odds ratio (OR), 1.95; 95% confidence interval (CI), 1.23-2.62] and TT [adjusted odds ratio (OR), 3.36; 95% confidence interval (CI), 1.46-8.74] had significantly increased esophageal cancer risk compared with those with MTHFR 667CC genotype. Folate intake was seen to have non-significant preventive effect. In former, moderate and heavy drinkers, a high esophageal cancer risk was observed for those with an MTHFR 677T allele genotype [ORs: 5.0(1.29-18.88), 3.70(1.83-7.66) and 5.77(2.11-15.72), respectively]. Significant interaction was found for moderate-heavy drinking and the MTHFR 677T allele genotype for esophageal cancer risk (p<0.05). Significant increased risk was also found in moderate and heavy smokers with the two genotypes [ORs: 3.58(1.64-7.80) and 4.51(1.15-17.78), respectively]. High folate intake and MTHFR 677TT was associated with a non-significant tendency for decreased esophageal cancer risk. Conclusion: Our finding supports the hypothesis that MTHFR C667T polymorphisms play a role in pathogenesis of esophageal cancer in the Chinese population. |
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Authors:
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Jing Lin; Runming Zeng; Rongcheng Luo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of cancer prevention : APJCP Volume: 12 ISSN: 1513-7368 ISO Abbreviation: Asian Pac. J. Cancer Prev. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130625 Medline TA: Asian Pac J Cancer Prev Country: Thailand |
Other Details:
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Languages: eng Pagination: 2019-23 Citation Subset: IM |
Affiliation:
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Department of Hospice, First Affiliated Hospital of Shantou University Medical College, Shantou, China E-mail sun_suxia@yahoo.com.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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