Document Detail

Folate intake and carcinogenesis of the colon and rectum.
MedLine Citation:
PMID:  1917236     Owner:  NLM     Status:  MEDLINE    
Experimental evidence suggests that folate depletion plays a role in carcinogenesis. A case-control study examining folate intake was conducted. Some 428 colon and 372 rectal cancer cases with matched neighbourhood controls were interviewed regarding usual intake of foods, including food preparation. Unadjusted folate was not associated with risk of either cancer. Controlling for kilocalories, odds ratios (ORs) for those with the highest folate intake were 0.5 (95% confidence interval (CI): 0.24-1.03) and 0.31 (95% CI: 0.16-0.59) for females and males for rectal cancer. There was no change in colon cancer risk associated with folate intake. There was an indication of an interaction of folate and alcohol intake; the difference in risk associated with low and high folate intake was highest for males in the highest alcohol category. Associations were of similar magnitude for other dietary factors correlated with folate. It appears that intake of folate or a correlated factor may be negatively related to risk of rectal cancer.
J L Freudenheim; S Graham; J R Marshall; B P Haughey; S Cholewinski; G Wilkinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of epidemiology     Volume:  20     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-11-08     Completed Date:  1991-11-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  368-74     Citation Subset:  IM    
Department of Social and Preventive Medicine, State University of New York, Buffalo 14214.
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MeSH Terms
Alcohol Drinking / adverse effects
Case-Control Studies
Colonic Neoplasms / epidemiology,  etiology,  prevention & control*
Folic Acid / administration & dosage*
Folic Acid Deficiency / complications
Food Handling
New York / epidemiology
Rectal Neoplasms / epidemiology,  etiology,  prevention & control*
Risk Factors
Sex Factors
Grant Support
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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