Document Detail

Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of therapy.
MedLine Citation:
PMID:  638084     Owner:  NLM     Status:  MEDLINE    
The utilization of [14C]formate for serine synthesis by lymphocytes was impaired in all the patients with pernicious anaemia and in 70% of other patients with megaloblastic anaemia. In pernicious anaemia this was corrected by vitamin B12 therapy in 48 h but not by folate therapy although patients given folate showed a satisfactory haematological response.
J Tikerpae; I Chanarin
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  38     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-06-17     Completed Date:  1978-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
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MeSH Terms
Anemia, Macrocytic / metabolism*
Anemia, Megaloblastic / drug therapy,  metabolism*
Anemia, Pernicious / metabolism
Folic Acid / metabolism*,  therapeutic use
Folic Acid Deficiency / metabolism
Formates / metabolism
Lymphocytes / metabolism*
Serine / biosynthesis*
Vitamin B 12 / therapeutic use
Vitamin B 12 Deficiency / metabolism
Reg. No./Substance:
0/Formates; 56-45-1/Serine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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