| Folate deficiency in the livers of diethylnitrosaminetreated rats. | |
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MedLine Citation:
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PMID: 1277187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of diethylnitrosamine on the metabolism of folic acid and related compounds in rat liver were investigated. The administration, in the drinking water, of diethynitrosamine to rats for 3 weeks led to decreased hepatic levels of folate, S-adenosylmethionine, and 5-methyltetrahydrofolate:homocysteine methyltransferase. Liver methylenetetrahydrofolate reductase levels were unaffected by administration of diethylnitrosamine. The polyglutamate fraction of hepatic folates obtained from rats treated with diethylnitrosamine for 3 weeks prior to injection with [3H]folate contained less radioactivity than did the polyglutamate fraction obtained from the livers of control rats treated with [3H]folate alone. Similarly, the polyglutamate folate fraction of rat livers that were simultaneously perfused with both diethylnitrosamine and [3H]folate contained less label than the polyglutamate fraction of rat livers perfused with [3H]folate only. Livers perfused with [2-14C]histidine and diethylnitrosamine produced more formiminoglutamate and less CO2 than livers treated with [2-14C]histidine only. The changes noted in the hepatic folate metabolism of diethylnitrosamine-treated rats resemble those seen in the livers of methyl-deficient rats. |
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Authors:
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Y S Buehring; L A Poirier; E L Stokstad |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 36 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1976 Aug |
Date Detail:
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Created Date: 1976-09-02 Completed Date: 1976-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2775-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diethylnitrosamine / pharmacology* Folic Acid Deficiency / chemically induced* Glutamates / metabolism Liver / drug effects*, metabolism Male Methionine / metabolism Methylation Nitrosamines / pharmacology* Rats S-Adenosylmethionine / metabolism Tetrahydrofolates / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Nitrosamines; 0/Tetrahydrofolates; 29908-03-0/S-Adenosylmethionine; 55-18-5/Diethylnitrosamine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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