| Folate conjugated poly(ester amine) for lung cancer therapy. | |
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MedLine Citation:
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PMID: 20358942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis. |
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Authors:
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Rohidas B Arote; Mi-Kyong Yoon; Tae-Hee Kim; Dhananjay Jere; Hu-Lin Jiang; You-Kyoung Kim; In-Kyu Park; Chong-Su Cho |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nanoscience and nanotechnology Volume: 10 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 3294-8 Citation Subset: IM |
Affiliation:
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School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage,
chemistry Cell Line, Tumor Cell Survival / drug effects Folic Acid / administration & dosage*, chemistry* Humans Lung Neoplasms / drug therapy*, pathology Macromolecular Substances / chemistry Materials Testing Molecular Conformation Nanocapsules / chemistry*, ultrastructure Nanomedicine / methods* Polyesters / chemistry* Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Macromolecular Substances; 0/Nanocapsules; 0/Polyesters; 24980-41-4/polycaprolactone; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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