Document Detail

Folate bioavailability in humans: effects of wheat bran and beans.
MedLine Citation:
PMID:  2827456     Owner:  NLM     Status:  MEDLINE    
The effect of wheat bran or California small white beans in the diet on absorption of monoglutamyl (PteGlu) and heptaglutamyl folic acid (PteGlu7) was studied in six men confined to a metabolic unit. Relative folate absorption was determined by measuring 24-h urinary folate excretion and serum folate levels at 0, 1, and 2 h after ingestion of a formula meal containing 1.13 mumol PteGlu or PteGlu7 (500 micrograms PteGlu equivalent). Serum data showed PteGlu absorption was more rapid than PteGlu7 absorption. Urinary excretion of PteGlu7 was 63% (50 less than or equal to mean less than or equal to 76%) of PteGlu excretion. Addition of 30 g wheat bran to the formula meal accelerated PteGlu absorption whereas PteGlu7 absorption was not significantly affected by either food. Effects of the two foods were qualitatively different. Wheat bran increased the absorption of PteGlu relative to PteGlu7 whereas beans minimized the difference between PteGlu and PteGlu7 serum areas.
P M Keagy; B Shane; S M Oace
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  47     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-12     Completed Date:  1988-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  80-8     Citation Subset:  AIM; IM    
Western Regional Research Center, ARS, USDA, Berkeley, CA 94710.
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MeSH Terms
Biological Availability
Dietary Fiber / administration & dosage*
Folic Acid / analysis,  pharmacokinetics*
Intestinal Absorption
Plants, Medicinal*
Research Design
Time Factors
Grant Support
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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