| Folate bioavailability: implications for establishing dietary recommendations and optimizing status. | |
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MedLine Citation:
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PMID: 20219964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The addition of folic acid to the US food supply, along with the critical role of folate in certain health outcomes, has intensified worldwide interest in the bioavailability of folate. Bioavailability is a function of absorptive and postabsorptive processes, which in turn are influenced by diet, individuality, and complex diet-host interactions. As such, it is unlikely that a single bioavailability figure will accurately reflect food folate bioavailability from every diet for every person. Although there is broad agreement that naturally occurring food folate is not as bioavailable as folic acid, questions remain as to the extent of these differences, particularly within the context of a whole diet. This article 1) summarizes and integrates bioavailability estimates derived from studies that use whole-diet approaches; 2) highlights the influences of genetics, ethnicity-race, and sex as postabsorptive bioavailability modifiers; and 3) discusses the adequacy of the US folate Recommended Dietary Allowance in achieving folate sufficiency in select subpopulations. |
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Authors:
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Marie A Caudill |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-10 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 91 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-28 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1455S-1460S Citation Subset: AIM; IM |
Affiliation:
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Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. mac379@cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Availability* Dietary Supplements Female Folic Acid / metabolism* Food, Fortified Homocysteine / metabolism Humans Intestinal Absorption Methionine / metabolism Middle Aged Nutrition Policy Nutritional Requirements* Premenopause Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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S06GM0539/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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