Document Detail


Folate, alcohol, and liver disease.
MedLine Citation:
PMID:  23136133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcoholic liver disease (ALD) is typically associated with folate deficiency, which is the result of reduced dietary folate intake, intestinal malabsorption, reduced liver uptake and storage, and increased urinary folate excretion. Folate deficiency favors the progression of liver disease through mechanisms that include its effects on methionine metabolism with consequences for DNA synthesis and stability and the epigenetic regulation of gene expression involved in pathways of liver injury. This paper reviews the pathogenesis of ALD with particular focus on ethanol-induced alterations in methionine metabolism, which may act in synergy with folate deficiency to decrease antioxidant defense as well as DNA stability while regulating epigenetic mechanisms of relevant gene expressions. We also review the current evidence available on potential treatments of ALD based on correcting abnormalities in methionine metabolism and the methylation regulation of relevant gene expressions.
Authors:
Valentina Medici; Charles H Halsted
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-08
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  57     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-04     Completed Date:  2013-10-29     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  596-606     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Alcohol Drinking / adverse effects*
Animals
Antioxidants / pharmacology
Disease Models, Animal
Epigenesis, Genetic / drug effects
Ethanol / administration & dosage,  adverse effects
Folic Acid / administration & dosage*,  pharmacokinetics,  urine
Folic Acid Deficiency / complications*,  drug therapy,  pathology
Gene Expression / drug effects
Humans
Intestine, Small / drug effects,  metabolism
Liver / drug effects,  pathology
Liver Diseases, Alcoholic / drug therapy,  etiology,  pathology*
Methionine / metabolism
Methylation
Grant Support
ID/Acronym/Agency:
K08 DK084111/DK/NIDDK NIH HHS; K08 DK084111/DK/NIDDK NIH HHS; R03 AA020577/AA/NIAAA NIH HHS; R03AA020577/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 3K9958V90M/Ethanol; 935E97BOY8/Folic Acid; AE28F7PNPL/Methionine
Comments/Corrections

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