Document Detail

Folate-conjugated micelles and their folate-receptor-mediated endocytosis.
MedLine Citation:
PMID:  19688723     Owner:  NLM     Status:  MEDLINE    
A folate-conjugated copolymer PEG-PLA-PLL/folate was synthesized and mixed with pure PEG-PLA-PLL and a fluorescent model drug mFITC to prepare folate-conjugated micelles. The distribution of micelles was studied on cancer-cell-bearing mice via frozen slicing. The results show that mFITC is successfully encapsulated into folate(+) and folate(-)micelles; PEG-PLA-PLL micelles the latter can be internalized by both HeLa and CHO cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by HeLa cells than by CHO cells. The folate(-)micelles showed retention in both organs and tumors. The folate(+)micelles are a promising active targeting drug delivery system for FR over-expressing cells and they accumulate in tumor beds.
Tiancheng Lu; Jing Sun; Xuexi Chen; Peibiao Zhang; Xiabin Jing
Related Documents :
19270723 - Adenovirus-mediated expression of uhrf1 reduces the radiosensitivity of cervical cancer...
20021053 - Ciprofloxacin-induced cytotoxicity and apoptosis in hela cells.
19020753 - Ectopic cyclin d1 overexpression increases chemosensitivity but not cell proliferation ...
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Macromolecular bioscience     Volume:  9     ISSN:  1616-5195     ISO Abbreviation:  Macromol Biosci     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1059-68     Citation Subset:  IM    
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biocompatible Materials / chemistry,  metabolism
CHO Cells
Carrier Proteins / metabolism*
Drug Carriers* / chemistry,  metabolism
Drug Delivery Systems
Endocytosis / physiology*
Folic Acid* / chemistry,  metabolism,  therapeutic use
Hela Cells
Materials Testing
Molecular Structure
Neoplasms / drug therapy,  pathology
Polymers / chemistry,  metabolism
Receptors, Cell Surface / metabolism*
Vitamin B Complex* / chemistry,  metabolism,  therapeutic use
Reg. No./Substance:
0/Biocompatible Materials; 0/Carrier Proteins; 0/Drug Carriers; 0/Micelles; 0/Polymers; 0/Receptors, Cell Surface; 0/folate-binding protein; 12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Vascularization in Bone Tissue Engineering: Physiology, Current Strategies, Major Hurdles and Future...
Next Document:  Alterations of the podocyte proteome in response to high glucose concentrations.