Document Detail


Fog-induced respiratory responses are attenuated by nedocromil sodium in humans.
MedLine Citation:
PMID:  11316646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fog inhalation induces cough and bronchoconstriction in patients with asthma, but only cough in normal subjects; whether it also influences the pattern of breathing is unclear. Nedocromil sodium (NCS) inhibits the cough response to inhalation of several pharmacological agents but its effects on fog-induced cough and changes in the pattern of breathing are unknown. We evaluated the effects of no drug, placebo, and 4- and 8-mg NCS administration on the cough threshold and changes in the pattern of breathing during fog inhalation in 14 healthy subjects. Measurements of tidal volume (VT), duration of inspiratory and expiratory times (TI and TE, respectively), total duration of the respiratory cycle (TT), mean inspiratory flow (VT/TI), duty cycle (TI/TT), respiratory frequency (f, 60/TT), and inspiratory minute ventilation (V I) were obtained by inductive plethysmography. Median cough threshold values were unaffected by placebo, but were increased (p < 0.01) by both NCS doses. In no-drug and placebo trials, inhalation of the threshold fog concentration caused increases in both VT/TI and V I (p always < 0.05) due to selective increases (p < 0.01) in VT. These changes were markedly attenuated by both NCS doses administration. Thus, fog induces coughing and increases in VT, VT/ TI, and V I in healthy subjects; NCS possesses antitussive effects and attenuates fog-induced changes in the pattern of breathing, possibly through inhibition of rapidly adapting "irritant" receptors.
Authors:
F Lavorini; G A Fontana; T Pantaleo; G Camiciottoli; W Castellani; N M Maluccio; M Pistolesi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  163     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-24     Completed Date:  2001-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1117-20     Citation Subset:  AIM; IM    
Affiliation:
Dipartimento di Area Critica Medico Chirurgica, Sezione di Medicina Respiratoria, Università di Firenze, Florence, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anti-Asthmatic Agents / pharmacology*
Bronchoconstriction / drug effects*
Cough*
Cross-Over Studies
Double-Blind Method
Female
Humans
Male
Nedocromil / pharmacology*
Plethysmography
Respiration / drug effects
Statistics, Nonparametric
Weather*
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 69049-73-6/Nedocromil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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