| Foetal volumetry using Magnetic Resonance Imaging in intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 22285415 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: We used magnetic resonance imaging (MRI) to perform volumetry of foetuses with and without growth restriction, and identify deviations in organ growth. STUDY DESIGN: 20 growth restricted and 19 normal foetuses were scanned once during pregnancy at gestational age 20.53-36.57weeks. MRI scans were performed on a 1.5T system using ssFSE sequences. Manual segmentation of whole body, brain, heart, lung, liver, thymus and kidney volume was performed. Data on the severity of foetal growth restriction and pregnancy outcome was collected. RESULTS: There was a significant reduction in foetal whole body volume and volume of all internal organs except the brain in growth restricted foetuses. A brain:liver ratio above 3.0 was associated with a 3.3 fold increase in risk of perinatal mortality (95% CI=1.68-6.47). CONCLUSION: MRI provides an accurate assessment of feotal organ growth. It may have a role to play in monitoring disease severity and the effect of future interventions. |
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Authors:
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Mellisa S Damodaram; Lisa Story; Elisanda Eixarch; Prachi Patkee; Abhilasha Patel; Sailesh Kumar; Mary Rutherford |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
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Title: Early human development Volume: - ISSN: 1872-6232 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Imperial College London, Hammersmith Campus, DuCane Road, London, W12 0HS, UK; Center for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare Trust, DuCane Road, London, W12 0HS, UK; MRC Imaging Science Department, Robert Steiner MRI Unit, Imperial College London, Hammersmith Hospital Campus, DuCane Road, London, W12 0HS, UK. |
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