| Foetal macrosomia in diabetic pregnancy. Further data on the association with maternal PGM1 genotype. | |
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MedLine Citation:
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PMID: 2959427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pattern of associations between maternal phosphoglucomutase locus 1 (PGM1) and foetal macrosomia in diabetic pregnancy has been compared with that observed in normal pregnancy. In diabetic pregnancy a substantial increase of macrosomic infants, as compared to normal pregnancy, is observed only among women homozygous for PGM1(1) allele. Also neonatal hypoglycemia is much more frequent in newborns from PGM1(-1) mothers than in newborns from other mothers. Since enzymatic activity of PGM1(-1) phenotype is lower as compared to other PGM1 phenotypes, this may influence glycaemic level and/or its stability in diabetic pregnant women with unfavourable effects on the metabolic and developmental patterns of the foetus. |
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Authors:
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N Lucarini; G Gerlini; F Gloria-Bottini; M C Gori; P Borgiani; M L Caprella; E Bottini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes research (Edinburgh, Scotland) Volume: 5 ISSN: 0265-5985 ISO Abbreviation: Diabetes Res. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-12-14 Completed Date: 1987-12-14 Revised Date: 2007-09-11 |
Medline Journal Info:
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Nlm Unique ID: 8502339 Medline TA: Diabetes Res Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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Chair of Human Development, 2nd University of Rome, School of Medicine, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 1
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enzymology,
genetics Diabetes Mellitus, Type 2 / enzymology, genetics Female Fetal Macrosomia / etiology*, genetics Genotype Humans Male Phosphoglucomutase / genetics* Pregnancy Pregnancy in Diabetics / enzymology, genetics* |
| Chemical | |
Reg. No./Substance:
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EC 5.4.2.2/Phosphoglucomutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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