| Foetal head growth retardation due to antiepileptic drugs: with reference to GH, TSH, T4, T3 and reverse T3 concentrations. | |
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MedLine Citation:
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PMID: 6684085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. The thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. The growth hormone level in the umbilical vein sample of the epileptic mother was lower than that in the controls. The correlations between the head circumference of an infant at delivery and the decreased levels of the hormones seemed to indicate that a decrease in the thyroxine level, caused by antiepileptic drugs, produced the foetal head growth retardation. |
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Authors:
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S Kaneko; T Hirano; Y Fukushima; T Sato; Y Nomura; S Shinagawa; Y Ogawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Folia psychiatrica et neurologica japonica Volume: 37 ISSN: 0015-5721 ISO Abbreviation: Folia Psychiatr Neurol Jpn Publication Date: 1983 |
Date Detail:
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Created Date: 1983-10-21 Completed Date: 1983-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372774 Medline TA: Folia Psychiatr Neurol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 25-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / adverse effects* Epilepsy / drug therapy* Female Fetal Growth Retardation / chemically induced* Growth Hormone / blood Humans Infant, Newborn Pituitary Hormones, Anterior / blood* Pregnancy Pregnancy Complications / drug therapy* Thyroid Hormones / blood* Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Pituitary Hormones, Anterior; 0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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