| Foetal growth determines cerebral ventricular volume in infants The Generation R Study. | |
| | |
MedLine Citation:
|
PMID: 18089296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cerebral ventricular system is a marker of brain development and a predictor of neurodevelopmental outcome. In premature or dysmature neonates, neuroanatomical structures including the ventricular system appear to be altered. The present study aims to provide information on the association between foetal growth and neonatal cerebral ventricular size in the normal population. Within the Generation R Study, a population-based cohort study, we used three-dimensional cranial ultrasound to determine lateral ventricular volume in 778 term infants aged 4-12 weeks. Foetal growth characteristics were repeatedly measured in early, mid- and late pregnancy and analysed in relation to ventricular volume divided by head circumference. Results revealed positive associations between foetal head circumference in late pregnancy and log-transformed ventricular volume (beta=0.077, 95% confidence interval (0.017; 0.136), equivalent to a 7.7% increase in ventricular volume per standard deviation of head circumference). Similarly, in a per week-longer gestational duration, ventricular volume in infancy was 6.0% larger. Multilevel modelling demonstrated that reduced growth of foetal head circumference and biparietal diameter during pregnancy were associated with decreased ventricular volume in infancy. In conclusion, foetal maturation is positively associated to cerebral ventricular size in term infants. Larger ventricular size in term infants needs to be distinguished from ventricular enlargement due to intraventricular haemorrhage or white matter damage in premature or dysmature infants. Moreover, the naturally occurring enlargement of ventricles during infancy should be considered in interpreting reports on increased ventricular volumes in several neuropsychiatric disorders. |
| | |
Authors:
|
Sabine J Roza; Paul P Govaert; Henri A Vrooman; Maarten H Lequin; Albert Hofman; Eric A P Steegers; Henriette A Moll; Vincent W V Jaddoe; Frank C Verhulst; Henning Tiemeier |
Related Documents
:
|
23045556 - Prevention of invasive cronobacter infections in young infants fed powdered infant form... 12015466 - Sequelae of chorioamnionitis. 3562816 - Strangulation in child abuse: ct diagnosis. 15520756 - Trends in severe brain injury and neurodevelopmental outcome in premature newborn infan... 9396536 - Cost-effectiveness in diagnosing infantile hypertrophic pyloric stenosis. 12373066 - Natural history of serum immunoglobulin concentrations in low birth weight infants and ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-21 |
Journal Detail:
|
Title: NeuroImage Volume: 39 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-02-05 Completed Date: 2008-05-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
|
Languages: eng Pagination: 1491-8 Citation Subset: IM |
Affiliation:
|
The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anthropometry Cerebral Ventricles / anatomy & histology*, embryology* Cohort Studies Female Fetal Development / physiology* Head / anatomy & histology Humans Image Processing, Computer-Assisted Infant Infant, Newborn Maternal Age Pregnancy Reference Values |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What determines drug solubility in lipid vehicles: is it predictable?
Next Document: Abnormal connections in the supraspinal bladder control network in women with urge urinary incontine...