Document Detail

Foetal experience: lifelong consequences.
MedLine Citation:
PMID:  17184488     Owner:  NLM     Status:  MEDLINE    
Modification of the foetal environment has lifelong consequences for endocrine function and behaviour. Maternal stress through activation of the hypothalamus-pituitary-adrenal axis can lead to increased anxiety levels and stress reactivity in offspring. Furthermore, these effects can pass across generations. The race is now on to understand the mechanisms involved and to find ways to prevent or reverse the effects of an "adverse" early environment in human populations.
Stephen G Matthews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  19     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-4     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Hypothalamo-Hypophyseal System / embryology
Mental Disorders / etiology
Obstetric Labor, Premature / psychology
Pituitary-Adrenal System / embryology
Pregnancy / psychology*
Prenatal Exposure Delayed Effects / etiology,  psychology*
Stress, Psychological / complications*

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