Document Detail

Focus on the short- and long-term effects of ghrelin on energy homeostasis.
MedLine Citation:
PMID:  20080032     Owner:  NLM     Status:  MEDLINE    
The endogenous ligand for the growth hormone secretagogue receptor, ghrelin, is a 28-amino-acid peptide acylated with an octanoyl group at the serine in position 3. Most of the circulating ghrelin results from its synthesis and secretion by the X/A-like endocrine cells from the stomach and proximal small intestine. Besides its potent growth hormone secretory action, ghrelin is a highly pleiotropic hormone, contributing significantly to the regulation of appetite and food intake control, gastrointestinal motility, gastric acid secretion, endocrine and exocrine pancreatic secretions, cell proliferation, glucose and lipid metabolism, and cardiovascular and immunologic processes. The purpose of this review is to consider the orexigenic effects of ghrelin on short-term regulation of food intake and long-term regulation of body weight, the implications of genetic ghrelin and growth hormone secretagogue receptor polymorphism, and the use of antagonists and agonists of ghrelin in pathophysiological conditions.
Carine De Vriese; Jason Perret; Christine Delporte
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-15
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  26     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-84     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Laboratory of Pharmaceutics and Biopharmaceutics, Université Libre de Bruxelles, Brussels, Belgium.
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MeSH Terms
Appetite Regulation*
Body Weight*
Cachexia / physiopathology
Energy Intake
Energy Metabolism*
Ghrelin / genetics,  metabolism*
Obesity / physiopathology
Polymorphism, Genetic
Receptors, Ghrelin / genetics
Reg. No./Substance:
0/Ghrelin; 0/Receptors, Ghrelin

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