| Focus on cystic fibrosis and other disorders evidenced in fetuses with sonographic finding of echogenic bowel: 16-year report from Brittany, France. | |
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MedLine Citation:
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PMID: 20932506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Pregnancies medical follow-up and ultrasonography development have enabled detection of fetal echogenic bowel, a sign associated with various pathologies, including cystic fibrosis. Based on the long experience of a region where cystic fibrosis is frequent (Brittany, France), we describe disorders diagnosed in fetal echogenic bowel fetuses and assess ultrasonography ability in detecting cystic fibrosis in utero. STUDY DESIGN: We reviewed the cases of fetal echogenic bowel diagnosed in pregnant women living in Brittany and referred for CFTR gene analysis over the 1992-2007 period (n = 289). RESULTS: A disorder was diagnosed in 32.2% of the fetuses, cystic fibrosis being the most commonly identified (7.6%). We also found digestive malformations (7.0%), chromosomal abnormalities (3.7%), and maternofetal infections (3.7%). Combining these data with our ongoing newborn screening program since 1989 showed that ultrasonography enabled diagnosis of 10.7% of the cystic fibrosis cases. CONCLUSION: This study highlights the importance of pregnancy ultrasound examinations and their efficiency in detecting cystic fibrosis. |
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Authors:
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Virginie Scotet; Ingrid Duguépéroux; Marie-Pierre Audrézet; Séverine Audebert-Bellanger; Matthieu Muller; Martine Blayau; Claude Férec |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-08 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 592.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Inserm U613, Faculté de Médecine et des Sciences de Santé, Université Brest, Etablissement Français du Sang Bretagne, Brest, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Cystic Fibrosis / epidemiology, genetics*, ultrasonography* Cystic Fibrosis Transmembrane Conductance Regulator / genetics Echogenic Bowel / epidemiology, ultrasonography* Female France / epidemiology Gestational Age Humans Incidence Pregnancy Retrospective Studies Risk Assessment Time Factors Ultrasonography, Prenatal* |
| Chemical | |
Reg. No./Substance:
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126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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