Document Detail

Focal seizures and aminophylline.
MedLine Citation:
PMID:  808758     Owner:  NLM     Status:  MEDLINE    
Intravenous aminophylline therapy for acute exacerbation of chronic obstructive pulmonary disease may trigger prolonged and difficult to control focal motor seizures with generalization. This can occur in previously neurologically asymptomatic patients and be associated with a poor outcome. Most patients exhibited periodic lateralized epileptiform discharges or had autopsy-proved focal central nervous system lesions, or both. If focal and generalized seizures develop during aminophylline therapy, drug toxicity should be suspect as announcing a focal central lesion. Careful individual monitoring of aminophylline dose and administration rate is essential.
P R Yarnell; N S Chu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  25     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  819-22     Citation Subset:  IM    
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MeSH Terms
Alcoholism / complications
Aminophylline / adverse effects*,  therapeutic use
Epilepsies, Partial / chemically induced*,  physiopathology
Lung Diseases, Obstructive / complications,  drug therapy
Middle Aged
Reg. No./Substance:

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