| Focal segmental glomerulosclerosis and hepatitis C virus: a case report. | |
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MedLine Citation:
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PMID: 11319519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Focal segmental glomerulosclerosis (FSGS) is a renal disease characterized by sclerotic segmentary lesions, involving a few glomeruli. Male-female ratio is >1 and, in the majority of cases, the patients are aged between 25 to 35 years. The clinical picture is similar to a nephrotic syndrome with non-selective proteinuria poorly sensitive to steroids and often associated with microhematuria. The etiology is still unknown, even in a prevalence in drug addicts, patients with AIDS and subjects with recurrent urological infections with vesico-ureteral reflux was observed. Recent reports showed that chronic infection Hepatitis C Virus (HCV)-related may be associate with or responsible for onset of some syndrome involving the kidney but not the liver. We report the case of a young woman with HCV-Ab positive chronic hepatitis that, during the disease, showed clinical findings of renal involvement, histologically related to a FSGS. We administered to her alpha-IFN at doses of 3 Mega Units thrice-a-week for six months. Serum HCV-RNA, proteinuria and hematuria disappeared simultaneously after the treatment. We underline that the lack of finding of HCV antigens or HCV-RNA in glomerular lesions (as occurred in our patient) does not rule out the virus role in pathogenesis of immunological nephritis. The recovery of our patient as well as the disappearance of proteinuria and hematuria during IFNalpha treatment may be further evidence that FSGS and chronic hepatitis HCV-related are not associated by chance. Further observations and perfectioning of diagnostic techniques are required to clarify the pathogenetic relationship between HCV and renal immunological syndromes. |
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Authors:
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M Motta; M Malaguarnera; N Restuccia; M Romano; E Vinci; G Pistone |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Panminerva medica Volume: 43 ISSN: 0031-0808 ISO Abbreviation: Panminerva Med Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-25 Completed Date: 2001-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421110 Medline TA: Panminerva Med Country: Italy |
Other Details:
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Languages: eng Pagination: 49-52 Citation Subset: IM |
Affiliation:
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Institute of Internal Medicine and Geriatrics, University of Catania, Catania, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use Female Glomerulosclerosis, Focal Segmental / virology* Hepatitis C, Chronic / complications*, drug therapy Humans Interferon-alpha / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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