Document Detail

Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
MedLine Citation:
PMID:  16095907     Owner:  NLM     Status:  MEDLINE    
Dyskinesias are a common consequence of dopaminergic therapy in patients with Parkinson's disease. Little is known about the influence of cellular replacement strategies upon drug-induced dyskinesias. In the current study, we employed parkinsonian rats to test whether the distribution of dopamine neuron grafts could differentially alter striatal circuitry and levodopa-induced dyskinesias. Specifically, we compared behavioral and neurochemical consequences of dopamine reinnervation restricted to a focal region of the striatum to innervation encompassing the majority of the striatum by distributing the same number of cells into single locus or multiple locations. Both the single-site and widespread grafts reduced pregraft dyskinesias and normalized FosB/DeltaFosB in the dorsal two-thirds of the lateral striatum. However, single-site DA graft recipients developed a robust, novel forelimb-facial stereotypy and upregulated FosB/DeltaFosB expression in the ventrolateral striatum, an area associated with movements of tongue and forelimbs. The onset of forelimb-facial stereotypy correlated with measures of increased graft function.
Eleonora Maries; Jeffrey H Kordower; Yaping Chu; Timothy J Collier; Caryl E Sortwell; Eliza Olaru; Kathleen Shannon; Kathy Steece-Collier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-08-10
Journal Detail:
Title:  Neurobiology of disease     Volume:  21     ISSN:  0969-9961     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-80     Citation Subset:  IM    
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N. Chicago, IL 60064, USA.
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MeSH Terms
Behavior, Animal
Brain Tissue Transplantation / adverse effects*,  methods
Corpus Striatum / surgery
Disease Models, Animal
Dopamine / physiology
Dyskinesias / etiology*,  physiopathology
Fetal Tissue Transplantation / adverse effects*,  methods
Mesencephalon / transplantation*
Parkinson Disease / physiopathology,  surgery*
Proto-Oncogene Proteins c-fos / metabolism
Rats, Inbred F344
Grant Support
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Sympatholytics; 1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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