Document Detail


Focal and multifocal diabetic neuropathies.
MedLine Citation:
PMID:  18345446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetic neuropathy is the most common neuropathy in industrialized countries, with a remarkable range of clinical manifestations. The vast majority of the patients with clinical diabetic neuropathy have a distal symmetrical form that progress following a fiber-length dependent pattern, with predominant sensory and autonomic manifestations. This pattern of neuropathy is associated with a progressive distal axonopathy. Patients are exposed to trophic changes in the feet, pains and autonomic disturbances. Less often, diabetic patients may develop focal and multifocal neuropathy that includes cranial nerve involvement, limb and truncal neuropathies. This neuropathic pattern tends to occur after 50 years of age, mostly in patients with longstanding diabetes mellitus. The LDDP does not show any trend to improvement and either relentlessly progresses or remain relatively stable over years. Conversely the focal diabetic neuropathies, which are often associated with inflammatory vasculopathy on nerve biopsies, remain self limited, sometimes after a relapsing course.
Authors:
Gérard Said
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  65     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-10-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1272-8     Citation Subset:  IM    
Affiliation:
l'Hôpital de Bicêtre, Université Paris-Sud. gerard.said@bct.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Diabetic Neuropathies / classification*,  pathology,  physiopathology,  therapy
Humans
Peripheral Nerves* / pathology,  physiopathology
Polyneuropathies* / pathology,  physiopathology

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