Document Detail


Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: a PET study with [18F]deoxyglucose.
MedLine Citation:
PMID:  8883104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven patients suffering from chronic disabling tinnitus underwent an FDG-PET study (positron emission tomography with [18F]deoxyglucose). Nine tinnitus patients revealed a significantly increased metabolic activity in the left, 1 in the right primary auditory cortex (PAC, Brodmann area 41). These results were statistically significant when compared to 14 healthy control individuals without tinnitus. A negative result was obtained from a chronic tinnitus patient but who had no subjective complaints during the period of PET investigation. One patient was first investigated during a disabling tinnitus period, later during a period with tinnitus relief and again when suffering from severe tinnitus. The metabolic activity of his left PAC was in good accordance with the subjective degree of tinnitus complaints present during each PET investigation. Although for the first time these results give objective evidence of tinnitus sensation and localization, they are difficult to interpret because of the limited research data available that combine functional brain imaging and acoustic stimuli.
Authors:
W Arnold; P Bartenstein; E Oestreicher; W Römer; M Schwaiger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  58     ISSN:  0301-1569     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Auditory Cortex / metabolism*,  radionuclide imaging
Chronic Disease
Deoxyglucose / analogs & derivatives*,  diagnostic use
Female
Fluorine Radioisotopes / diagnostic use*
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Sensation / physiology
Stereotaxic Techniques
Tinnitus / metabolism*,  physiopathology,  radionuclide imaging
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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