Document Detail


Focal electrical stimulation of major ganglion cell types in the primate retina for the design of visual prostheses.
MedLine Citation:
PMID:  23616529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrical stimulation of retinal neurons with an advanced retinal prosthesis may eventually provide high-resolution artificial vision to the blind. However, the success of future prostheses depends on the ability to activate the major parallel visual pathways of the human visual system. Electrical stimulation of the five numerically dominant retinal ganglion cell types was investigated by simultaneous stimulation and recording in isolated peripheral primate (Macaca sp.) retina using multi-electrode arrays. ON and OFF midget, ON and OFF parasol, and small bistratified ganglion cells could all be activated directly to fire a single spike with submillisecond latency using brief pulses of current within established safety limits. Thresholds for electrical stimulation were similar in all five cell types. In many cases, a single cell could be specifically activated without activating neighboring cells of the same type or other types. These findings support the feasibility of direct electrical stimulation of the major visual pathways at or near their native spatial and temporal resolution.
Authors:
Lauren H Jepson; Pawel Hottowy; Keith Mathieson; Deborah E Gunning; Wladyslaw Dabrowski; Alan M Litke; E J Chichilnisky
Related Documents :
25108309 - Repetitive magnetic stimulation induces plasticity of excitatory postsynapses on proxim...
24223569 - Identification of the epileptogenic zone from stereo-eeg signals: a connectivity-graph ...
24495809 - Specificity of stimulus-evoked fmri responses in the mouse: the influence of systemic p...
23839399 - 132 cortical-spinal neural prosthesis for restoring volitional limb movement in a paral...
24359469 - Artificial selection on relative brain size reveals a positive genetic correlation betw...
22961269 - Motor cortex and corticospinal excitability in humans with a history of illicit stimula...
17673499 - Erratum.
9120559 - Differential effects of 4-aminopyridine, serotonin, and phorbol esters on facilitation ...
20554849 - All that glitters ... dissociating attention and outcome expectancy from prediction err...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-06-25     Revised Date:  2013-10-28    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7194-205     Citation Subset:  IM    
Affiliation:
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Electric Stimulation / methods
Female
Macaca
Male
Photic Stimulation / methods
Prosthesis Design / methods*
Retina / cytology*,  physiology*
Retinal Ganglion Cells / physiology*
Visual Pathways / cytology,  physiology
Visual Prosthesis*
Grant Support
ID/Acronym/Agency:
5R21EB004410/EB/NIBIB NIH HHS; R01 EY021271/EY/NEI NIH HHS; R01EY021271/EY/NEI NIH HHS; R21 EB004410/EB/NIBIB NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.
Next Document:  Mitochondrial Exchanger NCLX Plays a Major Role in the Intracellular Ca2+ Signaling, Gliotransmissio...