Document Detail

Focal electrical stimulation of major ganglion cell types in the primate retina for the design of visual prostheses.
MedLine Citation:
PMID:  23616529     Owner:  NLM     Status:  MEDLINE    
Electrical stimulation of retinal neurons with an advanced retinal prosthesis may eventually provide high-resolution artificial vision to the blind. However, the success of future prostheses depends on the ability to activate the major parallel visual pathways of the human visual system. Electrical stimulation of the five numerically dominant retinal ganglion cell types was investigated by simultaneous stimulation and recording in isolated peripheral primate (Macaca sp.) retina using multi-electrode arrays. ON and OFF midget, ON and OFF parasol, and small bistratified ganglion cells could all be activated directly to fire a single spike with submillisecond latency using brief pulses of current within established safety limits. Thresholds for electrical stimulation were similar in all five cell types. In many cases, a single cell could be specifically activated without activating neighboring cells of the same type or other types. These findings support the feasibility of direct electrical stimulation of the major visual pathways at or near their native spatial and temporal resolution.
Lauren H Jepson; Pawel Hottowy; Keith Mathieson; Deborah E Gunning; Wladyslaw Dabrowski; Alan M Litke; E J Chichilnisky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-06-25     Revised Date:  2013-10-28    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7194-205     Citation Subset:  IM    
Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
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MeSH Terms
Electric Stimulation / methods
Photic Stimulation / methods
Prosthesis Design / methods*
Retina / cytology*,  physiology*
Retinal Ganglion Cells / physiology*
Visual Pathways / cytology,  physiology
Visual Prosthesis*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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