| Focal cortical dysplasia. Clinical-radiological-pathological associations. | |
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MedLine Citation:
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PMID: 22217526 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The term focal cortical dysplasia (FCD) describes a very particularly pathology of a migration disorder which involves a symptomatology mainly characterised by drug-resistant epileptic seizures, some particular neuroradiological images and histological characteristics, as well as a very positive response to surgical treatment in the majority of cases. MATERIAL AND METHODS: A total of 7 patients were studied, 6 children with a mean age of 34.3 months, and one 25 years old male, with very stubborn focal seizures and MRI images that showed FCD. RESULTS: Three of the patients (all girls) were operated on while very young, with extirpation of the FCD and the surrounding area, with the histopathology study showing agreement with the MRI images with the macroscopic study of the slices. The histology study showed typical findings of a Taylor-type FCD (poor definition between the cortical grey matter and the subcortical white matter, and "balloon cells"). Three years after the FCD three patients were cured of the seizures and with no anti-epilepsy medication. Two of them have seizure control with medication, another (the adult) is on the surgical waiting list, and the rest refused the operation. CONCLUSION: Taylor-type FCD is a disease associated to a great extent with drug-resistant focal seizures, that needs to be identified and extirpated as soon as possible, as surgery, well projected and performed, without leaving remains of dysplasia, can cure it in a high percentage of cases. |
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Authors:
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I Pascual-Castroviejo; J L Hernández-Moneo; M L Gutiérrez-Molina; J Viaño; S I Pascual-Pascual; R Velazquez-Fragua; C Morales; D Quiñones |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-2 |
Journal Detail:
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Title: Neurologia (Barcelona, Spain) Volume: - ISSN: 1578-1968 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005460 Medline TA: Neurologia Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Neurología Pediátrica, Hospital Universitario La Paz, Madrid, España. |
Vernacular Title:
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Displasia cortical focal. Correlaciones clínico-radiológicas-patológicas. |
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