| Focal, continuous spikes suggest cortical developmental abnormalities. Clinical, MRI and neuropathological correlates. | |
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MedLine Citation:
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PMID: 9875614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Widespread use of MRI now gives us increased insights into the different expressions of malformations of cortical development (MCD). The heterogeneity of these disorders are reflected by their varied clinical and neuroimaging features. Characteristic and intense scalp EEG abnormalities have been described in some patients. MATERIAL AND METHODS: We report the MRI and clinical findings of 3 adult patients (age 32-36) with a peculiar EEG pattern of distinct, localized, fast, continuous spiking. These patients represent all patients with such EEG findings that have been recognized by the first author during 9 years. RESULTS: MRI showed MCDs in all, respectively hemimegalencephaly, a subcortical heterotopion, and a focal cortical dysgenesis. The EEG findings had been stable since childhood and were posteriorly located. Two patients had fairly well controlled epilepsy in adult age. The third patient was incapacitated by persistent seizures and was treated with surgery. Histologically cortical dysplasia with neuronal clusters was found in this patient. Variable degrees of cognitive dysfunction were present in all. CONCLUSION: Focal, continuous, fast spiking is an unusual scalp EEG pattern. It is not an inevitable sign of severe epilepsy. It may suggest an MCD. It is not yet clear to what extent such findings are predictive of a dysgenetic etiology of epilepsy. |
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Authors:
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E Brodtkorb; K Andersen; O Henriksen; G Myhr; K Skullerud |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 98 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-06-15 Completed Date: 1999-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 377-85 Citation Subset: IM |
Affiliation:
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Department of Neurology, Trondheim University Hospital, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Adult Cerebral Cortex / abnormalities*, physiopathology* Electroencephalography Epilepsy / physiopathology Female Humans Magnetic Resonance Imaging Seizures / physiopathology |
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