| Focal changes of chronic pancreatitis and duct-arteriovenous relationships: avoiding a diagnostic pitfall. | |
| | |
MedLine Citation:
|
PMID: 16224220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A prior study of pancreatic duct-arteriovenous relationships suggested that finding ducts near muscularized blood vessels without intervening pancreatic acini indicated adenocarcinoma was present. Because focal changes of chronic pancreatitis are often seen at autopsy, it seemed reasonable to use the autopsy to test the hypothesis that this finding might be nonspecific. An unselected, consecutive series of 81 adult decedent pancreases without known pancreas cancer was evaluated for the presence of ducts near muscularized blood vessels, for fibrosis and/or atrophy, for chronic inflammation, and for duct reduplication and/or proliferation. Autolysis precluded assessment of 26% of the cases. Of evaluable cases, 37% displayed ducts near muscularized blood vessels without intervening pancreatic acini, 23% chronic inflammation, 62% fibrosis and/or atrophy, and 55% duct reduplication and/or proliferation. The finding of ducts near muscularized blood vessels was closely associated with fibrosis and/or atrophy (odds ratio = 28.87, chi = 14.59, P = 0.0001), with duct reduplication and/or proliferation (odds ratio = 19.23, chi = 15.88, P = 0.0001), but not with chronic inflammation (odds ratio = 1.41, chi = 0.05, P > 0.30). Because changes of chronic pancreatitis are associated with ducts near muscularized blood vessels and because chronic pancreatitis can mimic pancreas cancer, care should be exercised when using the finding of ducts near muscularized blood vessels without intervening pancreatic acini as a criterion for the diagnosis of pancreas cancer. |
| | |
Authors:
|
Mitchell S Wachtel; Elizabeth J Miller |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of surgical pathology Volume: 29 ISSN: 0147-5185 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-10-14 Completed Date: 2006-01-31 Revised Date: 2006-10-13 |
Medline Journal Info:
|
Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 1521-3 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Texas Tech University School of Medicine, Lubbock, TX, USA. wachtel@ttuhsc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arteries / pathology Chronic Disease Humans Pancreas / pathology* Pancreatic Ducts / blood supply, pathology* Pancreatic Neoplasms / pathology Pancreatitis / pathology* Veins / pathology |
| Comments/Corrections | |
Comment In:
|
Am J Surg Pathol. 2006 Sep;30(9):1203-5
[PMID:
16931969
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lymphomas of the female genital tract: a study of 186 cases and review of the literature.
Next Document: Composite glandular and endocrine tumors of the stomach with pancreatic acinar differentiation.