Document Detail

Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies.
MedLine Citation:
PMID:  22843258     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the association between the focal atrophy measures on antemortem MRI and postmortem neuropathologic classification of dementia with Lewy bodies (DLB) using the Third Report of the DLB Consortium criteria.
METHODS: We retrospectively identified 56 subjects who underwent antemortem MRI and had Lewy body (LB) pathology at autopsy. Subjects were pathologically classified as high (n = 25), intermediate (n = 22), and low likelihood DLB (n = 9) according to the Third Report of the DLB Consortium criteria. We included 2 additional pathologic comparison groups without LBs: one with low likelihood Alzheimer disease (AD) (control; n = 27) and one with high likelihood AD (n = 33). The associations between MRI-based volumetric measurements and the pathologic classification of DLB were tested with analysis of covariance by adjusting for age, sex, and MRI-to-death interval.
RESULTS: Antemortem hippocampal and amygdalar volumes increased from low to intermediate to high likelihood DLB (p < 0.001, trend test). Smaller hippocampal and amygdalar volumes were associated with higher Braak neurofibrillary tangle stage (p < 0.001). Antemortem dorsal mesopontine gray matter (GM) atrophy was found in those with high likelihood DLB compared with normal control subjects (p = 0.004) and those with AD (p = 0.01). Dorsal mesopontine GM volume decreased from low to intermediate to high likelihood DLB (p = 0.01, trend test).
CONCLUSION: Antemortem hippocampal and amygdalar volumes increase and dorsal mesopontine GM volumes decrease in patients with low to high likelihood DLB according to the Third Report of the DLB Consortium criteria. Patients with high likelihood DLB typically have normal hippocampal volumes but have atrophy in the dorsal mesopontine GM nuclei.
Kejal Kantarci; Tanis J Ferman; Bradley F Boeve; Stephen D Weigand; Scott Przybelski; Prashanthi Vemuri; Melissa E Murray; Melissa M Murray; Matthew L Senjem; Glenn E Smith; David S Knopman; Ronald C Petersen; Clifford R Jack; Joseph E Parisi; Dennis W Dickson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-25
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-07     Completed Date:  2012-10-15     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  553-60     Citation Subset:  AIM; IM    
Departments of Radiology, Mayo Clinic,Rochester, MN, USA.
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MeSH Terms
Aged, 80 and over
Atrophy / pathology
Brain / pathology*
Lewy Body Disease / classification*,  pathology*
Magnetic Resonance Imaging*
Grant Support
AG11378/AG/NIA NIH HHS; AG29550/AG/NIA NIH HHS; AG32306/AG/NIA NIH HHS; C06-RR018898/RR/NCRR NIH HHS; K99-AG037573/AG/NIA NIH HHS; P01-AG017216/AG/NIA NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; P50-NS072187/NS/NINDS NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01-AG040042/AG/NIA NIH HHS; R01-AG11378/AG/NIA NIH HHS; R01-AG15866/AG/NIA NIH HHS; R21-NS066147/NS/NINDS NIH HHS; U01-24904//PHS HHS; U01-96917//PHS HHS; U01-AG 06786/AG/NIA NIH HHS; U01-AG024904-01/AG/NIA NIH HHS; U24-AG26395/AG/NIA NIH HHS
Erratum In:
Neurology. 2012 Sep 4;79(10):1072
Note: Murray, Melissa M [corrected to Murray, Melissa E]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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