Document Detail


Focal microdialysis of CO₂ in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep.
MedLine Citation:
PMID:  22999917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether the perifornical-lateral hypothalamic area (PF-LHA), where the orexin neurons reside, is a central chemoreceptor site by microdialysis of artificial cerebrospinal fluid (aCSF) equilibrated with 25% CO(2) into PF-LHA in conscious rats. This treatment is known to produce a focal tissue acidification like that associated with a 6-7 mm Hg increase in arterial [Formula: see text] . Such focal acidification in the PF-LHA significantly increased ventilation up to 15% compared with microdialysis of normal aCSF equilibrated with 5% CO(2) only in wakefulness but not in sleep in both the dark (P=0.004) and light (P<0.001) phases of the diurnal cycle. This response was predominantly due to a significant increase in respiratory frequency (11%, P<0.001). There were no significant effects on ventilation in the group with probes misplaced outside the PF-LHA. These results suggest that PF-LHA functions as a central chemoreceptor site in the central nervous system in a vigilant state dependent manner with predominant effects in wakefulness.
Authors:
Ningjing Li; Aihua Li; Eugene Nattie
Related Documents :
12582827 - Visuomotor transformations affect bimanual coupling.
23997367 - The effect of respiratory scoring on the diagnosis and classification of sleep disorder...
23447057 - Mechanism of the dl-alpha-aminoadipic acid inhibitory effect on form-deprived myopia in...
8274547 - Kinematic description of variability of fast movements: analytical and experimental app...
19133287 - Sleep deprivation increases cigarette smoking.
23587557 - Balance dysfunction in hereditary and spontaneous spastic paraparesis.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-19
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  185     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-06-07     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  349-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Carbon Dioxide / metabolism*
Electroencephalography
Electromyography
Hypothalamus / metabolism*
Male
Microdialysis
Neural Pathways / physiology
Prefrontal Cortex / metabolism*
Pulmonary Ventilation / physiology*
Rats
Rats, Sprague-Dawley
Sleep Stages / physiology*
Wakefulness / physiology*
Grant Support
ID/Acronym/Agency:
HL 28066/HL/NHLBI NIH HHS; R01 HL028066/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute bronchodilation increases ventilatory complexity during resting breathing in stable COPD: towa...
Next Document:  Changes of attitudes toward epilepsy in college-preparatory high school students population: An indi...