Document Detail

Focal microdialysis of CO₂ in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep.
MedLine Citation:
PMID:  22999917     Owner:  NLM     Status:  MEDLINE    
We investigated whether the perifornical-lateral hypothalamic area (PF-LHA), where the orexin neurons reside, is a central chemoreceptor site by microdialysis of artificial cerebrospinal fluid (aCSF) equilibrated with 25% CO(2) into PF-LHA in conscious rats. This treatment is known to produce a focal tissue acidification like that associated with a 6-7 mm Hg increase in arterial [Formula: see text] . Such focal acidification in the PF-LHA significantly increased ventilation up to 15% compared with microdialysis of normal aCSF equilibrated with 5% CO(2) only in wakefulness but not in sleep in both the dark (P=0.004) and light (P<0.001) phases of the diurnal cycle. This response was predominantly due to a significant increase in respiratory frequency (11%, P<0.001). There were no significant effects on ventilation in the group with probes misplaced outside the PF-LHA. These results suggest that PF-LHA functions as a central chemoreceptor site in the central nervous system in a vigilant state dependent manner with predominant effects in wakefulness.
Ningjing Li; Aihua Li; Eugene Nattie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-19
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  185     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-06-07     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  349-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Analysis of Variance
Carbon Dioxide / metabolism*
Hypothalamus / metabolism*
Neural Pathways / physiology
Prefrontal Cortex / metabolism*
Pulmonary Ventilation / physiology*
Rats, Sprague-Dawley
Sleep Stages / physiology*
Wakefulness / physiology*
Grant Support
Reg. No./Substance:
142M471B3J/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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