| Focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of CT abnormality in PET/CT. | |
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MedLine Citation:
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PMID: 17895795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To demonstrate 3 cases of artifactual focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of any computed tomographic (CT) abnormality. MATERIALS AND METHODS: Three patients were examined: a 30-year-old man who had a positron emission tomography (PET)/computed tomography for restaging a biopsy-proven recurrence of head and neck cancer, a 68-year-old woman who was referred for initial staging of esophageal carcinoma, and a 57-year-old man who had a PET/computed tomography for initial staging of melanoma. In each case, there was intense focal activity in the lung parenchyma with no corresponding CT abnormality. Each patient was further evaluated with a repeat PET scan in days 1 and 3 in the first 2 cases and with a delayed repeat acquisition in the third case. Patients were followed for 24, 10, and 1 month, respectively. RESULTS: In the first 2 cases, the abnormal focal activity in the lungs had resolved in the repeat study. In the third case, the focus of increased activity in the lung had moved more peripherally in the delayed acquisition. Clinical follow-up was negative for disease in the corresponding pulmonary parenchymal sites. CONCLUSIONS: The finding of significant focal accumulation of fluoro-deoxy-glucose in the lung parenchyma in the absence of corresponding CT abnormality was artifactual. This was likely due to injection technique and the creation of particulate embolus. Positron emission tomography/Computed tomographic readers should be aware of this type of artifact to avoid misinterpretation. |
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Authors:
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Dimitrios Karantanis; Rathan M Subramaniam; Brian P Mullan; Patrick J Peller; Gregory A Wiseman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 31 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-09-26 Completed Date: 2007-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 800-5 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA. dkarantanis@nuclmed.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Esophageal Neoplasms / pathology, radiography, radionuclide imaging False Positive Reactions Female Fluorodeoxyglucose F18 / pharmacokinetics* Head and Neck Neoplasms / pathology, radiography, radionuclide imaging Humans Lung Neoplasms / radiography*, radionuclide imaging*, secondary Male Melanoma / radiography, radionuclide imaging, secondary Middle Aged Mouth Neoplasms / pathology, radiography, radionuclide imaging Neoplasm Staging Positron-Emission Tomography Radiopharmaceuticals / pharmacokinetics* Tomography, X-Ray Computed Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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