Document Detail

Foamy histiocytosis of the spleen in patients with chronic thrombocytopenia.
MedLine Citation:
PMID:  1251138     Owner:  NLM     Status:  MEDLINE    
In 17 of the 64 spleens removed from patients with chronic thrombocytopenia lipid-laden histiocytotes were demonstrated. No correlation was found between these pathological findings and the age of the patients at diagnosis or splenectomy, the duration before splenectomy of therapy with glucocorticoids, the period with thrombocytopenia or the platelet count. 7 of the patients, who relapsed after splenectomy had lipid-laden histiocytes in their spleens i.e. 58% of the patients with relapse, compared with 10 patients with foamy histiocytosis and without relapse i.e. 19% of the patients without relapse. At follow up, 3 of the 17 patients with splenic histiocytosis still had thrombocytopenia, compared with 1 of the 47 patients without foamy cells. Foamy histiocytosis of the spleen from a patient with chronic thrombocytopenia may indicate a dubious prognosis.
J Cohn; I Tygstrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  16     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-04-30     Completed Date:  1976-04-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Lipid Metabolism
Spleen / pathology*
Thrombocytopenia / pathology*,  therapy

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