| Fluvoxamine inhibits weight gain and food intake in food restricted hyperphagic Wistar rats. | |
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MedLine Citation:
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PMID: 19043208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), were studied in normophagic and food-restriction-induced hyperphagic middle-aged Wistar rats. Normophagic intact Wistar rats were given fluvoxamine (100 mg/kg/d, per os (p.o.)) or vehicle for 10 d. Hyperphagic middle-aged Wistar rats were subjected to 10 d of food restriction; they were allowed to refeed for 10 d, with ad libitum food access and administered fluvoxamine (100 mg/kg/d, p.o.) or vehicle during the 10-d refeeding period. Fluvoxamine administration to normophagic middle-aged Wistar rats affected neither their weight nor food intake. However, administration to food-restricted rats showed inhibitory effects of weight gain and food intake during 10 d of refeeding. Fluvoxamine-treated rats showed significantly lower neuropeptide Y (NPY) immunostaining levels in the paraventricular nucleus (PVN) and dorsomedial hypothalamic nucleus (DMH) than untreated controls. Hypophagic and weight-inhibiting effects of fluvoxamine might be mediated via decreased NPY in PVN and DMH. These results suggest that the appetite-controlling effect of fluvoxamine might be responsive to the rats' appetite condition. |
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Authors:
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Tomokazu Shinozaki; Masaki Kimura; Makoto Hosoyamada; Toshiaki Shibasaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 31 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 2250-4 Citation Subset: IM |
Affiliation:
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Division of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidepressive Agents, Second-Generation / pharmacology* Body Weight / drug effects Eating / drug effects* Fluvoxamine / pharmacology* Hyperphagia / psychology* Hypothalamus / drug effects, physiology Male Neuropeptide Y / physiology Rats Rats, Wistar Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 0/Neuropeptide Y; 54739-18-3/Fluvoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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