Document Detail


Fluvoxamine inhibits weight gain and food intake in food restricted hyperphagic Wistar rats.
MedLine Citation:
PMID:  19043208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), were studied in normophagic and food-restriction-induced hyperphagic middle-aged Wistar rats. Normophagic intact Wistar rats were given fluvoxamine (100 mg/kg/d, per os (p.o.)) or vehicle for 10 d. Hyperphagic middle-aged Wistar rats were subjected to 10 d of food restriction; they were allowed to refeed for 10 d, with ad libitum food access and administered fluvoxamine (100 mg/kg/d, p.o.) or vehicle during the 10-d refeeding period. Fluvoxamine administration to normophagic middle-aged Wistar rats affected neither their weight nor food intake. However, administration to food-restricted rats showed inhibitory effects of weight gain and food intake during 10 d of refeeding. Fluvoxamine-treated rats showed significantly lower neuropeptide Y (NPY) immunostaining levels in the paraventricular nucleus (PVN) and dorsomedial hypothalamic nucleus (DMH) than untreated controls. Hypophagic and weight-inhibiting effects of fluvoxamine might be mediated via decreased NPY in PVN and DMH. These results suggest that the appetite-controlling effect of fluvoxamine might be responsive to the rats' appetite condition.
Authors:
Tomokazu Shinozaki; Masaki Kimura; Makoto Hosoyamada; Toshiaki Shibasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  31     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2250-4     Citation Subset:  IM    
Affiliation:
Division of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents, Second-Generation / pharmacology*
Body Weight / drug effects
Eating / drug effects*
Fluvoxamine / pharmacology*
Hyperphagia / psychology*
Hypothalamus / drug effects,  physiology
Male
Neuropeptide Y / physiology
Rats
Rats, Wistar
Weight Gain / drug effects*
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Neuropeptide Y; 54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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