| Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women. | |
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MedLine Citation:
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PMID: 21047568 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The acute-phase response (APR) to aminobisphosphonates is triggered by activation of γδ T cells, resulting in pro-inflammatory cytokine release. Statins prevent aminobisphosphonate-induced γδ T cell activation in vitro, raising the possibility that statins might prevent the APR in vivo. The objective of this study was to determine whether fluvastatin prevents the APR to zoledronic acid in post-menopausal women. A double-blind, randomised, placebo-controlled study was conducted in 60 healthy, post-menopausal, female volunteers (mean age 60.6±4.0). Volunteers received 5mg zoledronic acid by intravenous infusion, and either three times 40mg fluvastatin (0hr, 24hr and 48hr), 40mg fluvastatin (0hr) plus placebo (24hr and 48hr), or placebo (0hr, 24hr and 48hr), orally. Post-infusion symptoms were assessed by questionnaire. Changes in γδ T cell levels, pro-inflammatory cytokines (TNFα, IFNγ, IL-6) and C-reactive protein (CRP) were measured in peripheral blood at various time-points post-infusion. Zoledronic acid administration triggered increased serum levels of TNFα, IFNγ, IL-6 and CRP in ≥70% of study volunteers, whilst characteristic APR symptoms were observed in >50% of participants. Zoledronic acid also induced a transient fall in circulating Vγ9Vδ2 T cell levels at 48hr, consistent with Vγ9Vδ2 T cell activation. Concurrent fluvastatin administration did not prevent zoledronic acid-induced cytokine release, alter circulating Vγ9Vδ2 T cell levels, nor diminish the frequency or severity of APR symptoms. In conclusion, intravenous zoledronic acid induced pro-inflammatory cytokine release and APR symptoms in the majority of study participants, which was not prevented by co-administration of fluvastatin. This article is part of a Special Issue entitled Bisphosphonates. |
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Authors:
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Keith Thompson; Fran Keech; David J McLernon; Kumar Vinod; Robin J May; William G Simpson; Michael J Rogers; David M Reid |
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Publication Detail:
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Type: Journal Article Date: 2010-10-31 |
Journal Detail:
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Title: Bone Volume: 49 ISSN: 1873-2763 ISO Abbreviation: Bone Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: United States |
Other Details:
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Languages: eng Pagination: 140-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Applied Medicine, University of Aberdeen, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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