| Fluticasone propionate/salmeterol and exercise-induced asthma in children with persistent asthma. | |
| | |
MedLine Citation:
|
PMID: 19382218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE: Exercise is a common trigger in children with persistent asthma and inhaled corticosteroids have been shown to effectively treat clinical manifestations of persistent asthma, including protection from decrements in lung function caused by exercise. The goal of this study was to evaluate the effectiveness of fluticasone propionate/salmeterol 100/50 mcg compared with fluticasone propionate 100 mcg for the prevention of airflow limitation triggered by standardized exercise challenge in pediatric and adolescent patients with persistent asthma. METHODS: Multicenter, randomized, double-blind, parallel group trial of 248 subjects with persistent asthma (age 4-17 years) randomized to receive fluticasone propionate/salmeterol (100/50 mcg twice daily) or fluticasone propionate alone (100 mcg twice daily) via Diskus for 4 weeks. Exercise challenge tests were performed during screening and approximately 8 hr after administration of the blinded study medication on Treatment Day 28. RESULTS: After 4 weeks of therapy both treatments provided protection following exercise challenge. The protection estimated by the maximal fall in FEV(1) was significantly better for fluticasone propionate/salmeterol (9.5 +/- 0.8% [mean +/- SE]) compared with fluticasone propionate alone (12.7 +/- 1.1%, P = 0.021). Statistically significant differences were not observed for asthma rescue-free days and asthma symptom-free days. CONCLUSION: Chronic dosing with fluticasone propionate/salmeterol in a single device provides superior protection compared with an inhaled corticosteroid alone in protecting against exercise-induced asthma in children with persistent asthma. |
| | |
Authors:
|
David Pearlman; Paul Qaqundah; Jonathan Matz; Steven W Yancey; David A Stempel; Hector G Ortega |
Related Documents
:
|
1974688 - Efficacy of formoterol metered aerosol in children. 7065478 - Effect of oral terbutaline on exercise-induced asthma. 12296528 - Pulmonary problems and management concerns in youth sports. 12113218 - H1-antihistamines in asthma. 11299288 - Intracellular signaling specificity in skeletal muscle in response to different modes o... 1680108 - Aerobic exercise training in an aids risk group. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric pulmonology Volume: 44 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-27 Completed Date: 2009-08-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
|
Languages: eng Pagination: 429-35 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Wiley-Liss, Inc. |
Affiliation:
|
Colorado Allergy and Asthma Centers, PC, Denver, Colorado, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Adolescent Albuterol / administration & dosage, analogs & derivatives* Androstadienes / administration & dosage* Asthma, Exercise-Induced / prevention & control* Bronchodilator Agents / administration & dosage* Child Child, Preschool Drug Combinations Female Forced Expiratory Volume Humans Male |
| Chemical | |
Reg. No./Substance:
|
0/Androstadienes; 0/Bronchodilator Agents; 0/Drug Combinations; 18559-94-9/Albuterol; 89365-50-4/salmeterol; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery.
Next Document: Predicting changes in clinical status of young asthmatics: clinical scores or objective parameters?