Document Detail

Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats.
MedLine Citation:
PMID:  4070407     Owner:  NLM     Status:  MEDLINE    
Recent studies indicate that fluprazine hydrochloride reduces offensive attack in laboratory rats and mice without decreasing defensive behavior during conspecific encounters. Since wild rats and rats displaying the "septal lesion syndrome" show much more pronounced defensive reactions than do normal laboratory rats, these animals were used to provide a more critical test of fluprazine's effectiveness on defense. When a dose of fluprazine hydrochloride (8 mg/kg), previously shown to be highly effective in reducing or eliminating offense, was given to wild and septal syndrome rats these animals showed no reliable decrement in a wide range of defensive reactions including biting attack (defensive attack) to human handling and other stimulation. These findings support the view that fluprazine does not appreciably affect defensive attack or other defensive behaviors even though it strongly inhibits offensive attack.
D C Blanchard; R Takushi; R J Blanchard; K J Flannelly; E D Kemble
Related Documents :
22701407 - A rat model of post-traumatic stress disorder reproduces the hippocampal deficits seen ...
8816267 - Recovery of olfactory function in thirteen-day-old rats after olfactory bulb transplant...
17988657 - The role of organic cation transporter-3 in methamphetamine disposition and its behavio...
8225947 - The effect of peripheral inositol injection on rat motor activity models of depression.
929627 - The hydrolysis of flavouring esters by artificial gastrointestinal juices and rat tissu...
8736117 - Losartan (dup-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intrac...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  35     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aggression / drug effects*
Animals, Wild
Brain Diseases / drug therapy
Piperazines / pharmacology*
Septum Pellucidum*
Startle Reaction / drug effects
Grant Support
Reg. No./Substance:
0/Piperazines; 76716-60-4/fluprazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Paradoxical sleep augmentation after imprinting in the domestic chick.
Next Document:  At what age do rat young stop responding to the maternal pheromone?