Document Detail


Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats.
MedLine Citation:
PMID:  4070407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies indicate that fluprazine hydrochloride reduces offensive attack in laboratory rats and mice without decreasing defensive behavior during conspecific encounters. Since wild rats and rats displaying the "septal lesion syndrome" show much more pronounced defensive reactions than do normal laboratory rats, these animals were used to provide a more critical test of fluprazine's effectiveness on defense. When a dose of fluprazine hydrochloride (8 mg/kg), previously shown to be highly effective in reducing or eliminating offense, was given to wild and septal syndrome rats these animals showed no reliable decrement in a wide range of defensive reactions including biting attack (defensive attack) to human handling and other stimulation. These findings support the view that fluprazine does not appreciably affect defensive attack or other defensive behaviors even though it strongly inhibits offensive attack.
Authors:
D C Blanchard; R Takushi; R J Blanchard; K J Flannelly; E D Kemble
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  35     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aggression / drug effects*
Animals
Animals, Wild
Brain Diseases / drug therapy
Piperazines / pharmacology*
Rats
Septum Pellucidum*
Startle Reaction / drug effects
Syndrome
Grant Support
ID/Acronym/Agency:
707 RR07026/RR/NCRR NIH HHS; AA 06220/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Piperazines; 76716-60-4/fluprazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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