| Fluoxetine and nortriptyline affect NTPDase and 5'-nucleotidase activities in rat blood serum. | |
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MedLine Citation:
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PMID: 17889906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Depression is a serious condition associated with considerable morbidity and mortality. Selective serotonin reuptake inhibitors and tricyclic antidepressants, such as fluoxetine and nortriptyline, respectively, were commonly used in treatment for depression. Selective serotonin reuptake inhibitors have been associated with increased risk of bleeding complications, possibly as a result of inhibition of platelet aggregation. ATP, ADP and adenosine are signaling molecules in the vascular system and nucleotidases activities are considered an important thromboregulatory system which functions in the maintenance of blood fluidity. Therefore, here we investigate the effect of in vivo (acute and chronic) and in vitro treatments with the antidepressant drugs on nucleotidases activities in rat blood serum. In acute treatment, nortriptyline decreased ATP hydrolysis (41%), but not altered ADP and AMP hydrolysis. In contrast, fluoxetine did not alter NTPDase and ecto-5'-nucleotidase activities. A significant inhibition of ATP, ADP, and AMP hydrolysis were observed in chronic treatment with fluoxetine (60%, 32%, and 42% for ATP, ADP, and AMP hydrolysis, respectively). Similar effects were shown in chronic treatment with nortriptyline (37%, 41%, and 30% for ATP, ADP, and AMP hydrolysis, respectively). In addition, there were no significant changes in NTPDase and ecto-5'-nucleotidase activities when fluoxetine and nortriptyline (100, 250, and 500 microM) were tested in vitro. Our results have shown that fluoxetine and nortriptyline changed the nucleotide catabolism, suggesting that homeostasis of vascular system can be altered by antidepressant treatments. |
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Authors:
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Eduardo Luiz Pedrazza; Mario Roberto Senger; Eduardo Pacheco Rico; Fernanda Francine Zimmermann; Leonardo Pedrazza; João José de Freitas Sarkis; Carla Denise Bonan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-29 |
Journal Detail:
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Title: Life sciences Volume: 81 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-09 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 1205-10 Citation Subset: IM |
Affiliation:
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Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul. Avenida Ipiranga, 6681, 90619-900, Porto Alegre, RS, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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5'-Nucleotidase
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blood*,
metabolism Animals Antidepressive Agents / administration & dosage, pharmacology* Blood Coagulation / drug effects Dose-Response Relationship, Drug Fluoxetine / administration & dosage, pharmacology* Male Nortriptyline / administration & dosage, pharmacology* Nucleoside-Triphosphatase / blood*, metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 54910-89-3/Fluoxetine; 72-69-5/Nortriptyline; EC 3.1.3.5/5'-Nucleotidase; EC 3.6.1.15/Nucleoside-Triphosphatase |
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