Document Detail

Fluoxetine-induced bradycardia and syncope in two patients.
MedLine Citation:
PMID:  2211552     Owner:  NLM     Status:  MEDLINE    
Fluoxetine appears to cause a low incidence of adverse cardiac effects. An uncommon but potentially hazardous effect of fluoxetine therapy, however, is bradycardia accompanied by faintness or syncope. The authors report two cases in which this adverse effect occurred. They hypothesize that the mechanism of bradycardia in these cases represents a direct central nervous system effect of increased serotonin on medullary cardiovascular regulation.
J M Ellison; J E Milofsky; E Ely
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  51     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-01     Completed Date:  1990-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-6     Citation Subset:  IM    
Department of Psychiatry, Cambridge Hospital, MA 02139.
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MeSH Terms
Bradycardia / chemically induced*
Depressive Disorder / drug therapy*
Fluoxetine / adverse effects*,  therapeutic use
Hypotension, Orthostatic / chemically induced
Syncope / chemically induced*
Reg. No./Substance:
Comment In:
J Clin Psychiatry. 1991 Mar;52(3):139   [PMID:  2005082 ]

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