Document Detail

Fluoxetine hydrochloride for the treatment of severe refractory orthostatic hypotension.
MedLine Citation:
PMID:  7942939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the usefulness of fluoxetine hydrochloride in the treatment of patients with severe refractory orthostatic hypotension. DESIGN: Prospective, nonrandomized study. PATIENTS: Five patients (3 men, 2 women with a mean age of 67 +/- 7 years with chronic symptomatic orthostatic hypotension resistant to or intolerant of other therapies. METHODS: Symptoms and orthostatic responses were recorded in the baseline state. Fluoxetine hydrochloride 20 mg orally once daily was started and patients were reevaluated after 6 to 8 weeks of therapy. RESULTS: All patients demonstrated orthostatic hypotension (20 mm Hg or greater decline in systolic blood pressure) associated with symptoms (eg, dizziness, vertigo, near syncope) in the baseline state. After 6 to 8 weeks of fluoxetine therapy, 2 patients reported resolution of all symptoms, 2 had a marked reduction in symptoms, and 1 patient experienced no effect. Orthostatic responses were attenuated in 4 of the 5 patients (80%). CONCLUSION: Fluoxetine hydrochloride may be an effective therapy for some patients with recurrent severe orthostatic hypotension refractory to other forms of therapy.
B P Grubb; D Samoil; D Kosinski; D Wolfe; M Lorton; E Madu
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  97     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-03     Completed Date:  1994-11-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  366-8     Citation Subset:  AIM; IM; S    
Department of Medicine, Medical College of Ohio, Toledo 43699.
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MeSH Terms
Fluoxetine / therapeutic use*
Hypotension, Orthostatic / drug therapy*
Middle Aged
Prospective Studies
Treatment Outcome
Reg. No./Substance:

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