| Fluoxetine hydrochloride for the treatment of severe refractory orthostatic hypotension. | |
| | |
MedLine Citation:
|
PMID: 7942939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the usefulness of fluoxetine hydrochloride in the treatment of patients with severe refractory orthostatic hypotension. DESIGN: Prospective, nonrandomized study. PATIENTS: Five patients (3 men, 2 women with a mean age of 67 +/- 7 years with chronic symptomatic orthostatic hypotension resistant to or intolerant of other therapies. METHODS: Symptoms and orthostatic responses were recorded in the baseline state. Fluoxetine hydrochloride 20 mg orally once daily was started and patients were reevaluated after 6 to 8 weeks of therapy. RESULTS: All patients demonstrated orthostatic hypotension (20 mm Hg or greater decline in systolic blood pressure) associated with symptoms (eg, dizziness, vertigo, near syncope) in the baseline state. After 6 to 8 weeks of fluoxetine therapy, 2 patients reported resolution of all symptoms, 2 had a marked reduction in symptoms, and 1 patient experienced no effect. Orthostatic responses were attenuated in 4 of the 5 patients (80%). CONCLUSION: Fluoxetine hydrochloride may be an effective therapy for some patients with recurrent severe orthostatic hypotension refractory to other forms of therapy. |
| | |
Authors:
|
B P Grubb; D Samoil; D Kosinski; D Wolfe; M Lorton; E Madu |
Related Documents
:
|
3661389 - Prognosis after cardiac arrest due to ventricular tachycardia or ventricular fibrillati... 7885939 - Ventriculoatrial conduction in patients with implantable cardioverter defibrillators: i... 7596699 - Accelerated idioventricular rhythm: a benign arrhythmia in childhood. 2401059 - Top-resolution frequency analysis of electrocardiogram with adaptive frequency determin... 6849269 - Electrophysiologic testing in the management of survivors of out-of-hospital cardiac ar... 10549909 - Identification of ventricular late potentials in the surface electrocardiogram during a... 1924679 - Proximal cutaneous necrosis associated with small vessel calcification in renal failure. 12052409 - Primary anti-phospholipid antibody syndrome (aps): current concepts. 9071929 - Oesophageal manometry in the evaluation of megacolon with onset in adult life. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: The American journal of medicine Volume: 97 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1994 Oct |
Date Detail:
|
Created Date: 1994-11-03 Completed Date: 1994-11-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 366-8 Citation Subset: AIM; IM; S |
Affiliation:
|
Department of Medicine, Medical College of Ohio, Toledo 43699. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Fluoxetine / therapeutic use* Humans Hypotension, Orthostatic / drug therapy* Male Middle Aged Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonspecific intestinal adsorption of levothyroxine by aluminum hydroxide.
Next Document: Toxic effects of intravenous and oral prostaglandin E therapy in patients with liver disease.