| Fluoxetine and desipramine in major depressive disorder. | |
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MedLine Citation:
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PMID: 8227488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of fluoxetine and desipramine were compared in a 6-week double-blind, parallel group study of patients with major depression. Twenty-five were studied while hospitalized for treatment, and 33 were studied as outpatients. Improvement on the Hamilton Rating Scale for Depression was significant for both treatments from week 1 through the end of the study and did not differ between the two treatments at any week. Overall, 64% of fluoxetine-treated patients and 68% of desipramine-treated patients had at least a 50% reduction in Hamilton Depression score. We assessed whether improvement relatively early in treatment was predictive of categorical response at 6 weeks. Among fluoxetine-treated patients, but not desipramine-treated patients, the week 3 change in the Hamilton Depression mood item was significantly predictive of the response at 6 weeks. Patients treated with fluoxetine had significantly fewer side effects than those treated with desipramine. Desipramine, but not fluoxetine, caused a persistent increase in heart rate. The results suggest that early signs of response to fluoxetine are not dependent on achieving steady-state levels of the drug. |
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Authors:
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C L Bowden; A F Schatzberg; A Rosenbaum; S A Contreras; J A Samson; E Dessain; M Sayler |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 13 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-17 Completed Date: 1993-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 305-11 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Depressive Disorder / drug therapy*, psychology Desipramine / adverse effects, therapeutic use* Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Fluoxetine / adverse effects, therapeutic use* Humans Male Middle Aged Personality Inventory |
| Chemical | |
Reg. No./Substance:
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50-47-5/Desipramine; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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