Document Detail

Fluoxetine and desipramine in major depressive disorder.
MedLine Citation:
PMID:  8227488     Owner:  NLM     Status:  MEDLINE    
The efficacy and safety of fluoxetine and desipramine were compared in a 6-week double-blind, parallel group study of patients with major depression. Twenty-five were studied while hospitalized for treatment, and 33 were studied as outpatients. Improvement on the Hamilton Rating Scale for Depression was significant for both treatments from week 1 through the end of the study and did not differ between the two treatments at any week. Overall, 64% of fluoxetine-treated patients and 68% of desipramine-treated patients had at least a 50% reduction in Hamilton Depression score. We assessed whether improvement relatively early in treatment was predictive of categorical response at 6 weeks. Among fluoxetine-treated patients, but not desipramine-treated patients, the week 3 change in the Hamilton Depression mood item was significantly predictive of the response at 6 weeks. Patients treated with fluoxetine had significantly fewer side effects than those treated with desipramine. Desipramine, but not fluoxetine, caused a persistent increase in heart rate. The results suggest that early signs of response to fluoxetine are not dependent on achieving steady-state levels of the drug.
C L Bowden; A F Schatzberg; A Rosenbaum; S A Contreras; J A Samson; E Dessain; M Sayler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  13     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-12-17     Completed Date:  1993-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.
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MeSH Terms
Depressive Disorder / drug therapy*,  psychology
Desipramine / adverse effects,  therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Fluoxetine / adverse effects,  therapeutic use*
Middle Aged
Personality Inventory
Reg. No./Substance:
50-47-5/Desipramine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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