| Fluoxetine, 17-β estradiol or folic acid combined with intra-lateral septal infusions of neuropeptide Y produced antidepressant-like actions in ovariectomized rats forced to swim. | |
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MedLine Citation:
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PMID: 21971371 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Folic acid is antidepressant, either alone or combined with several antidepressant drugs. However, the antidepressant-like actions of folic acid combined with intra-lateral septal (LSN) infusions of neuropeptide Y (NPY) in the forced swimming test (FST) have not been tested before. Thus, systemic injections of fluoxetine (20.0mg/kg, P<0.05; s.c.) or 17-β estradiol (10.0μg/rat, P<0.05; s.c.) or oral administrations of folic acid (50.0mg/kg, P<0.05; 75.0mg/kg, P<0.05) or NPY intra-LSN (3.0μg, P<0.05; 3.5μg, P<0.05) reduced immobility of ovariectomized Wistar rats. Subthreshold doses of: folic acid (25.0mg/kg) or 17-β estradiol (5.0μg/rat, P<0.05) or fluoxetine (15.0mg/kg, P<0.05; s.c.) combined with subthreshold doses of NPY (2.5μg/rat, P<0.05; intra-LSN) and these combinations produced antidepressant-like actions; which were canceled by BIBP 3226 (a NPY-Y1 receptor antagonist). It is concluded that folic acid produced antidepressant-like effects probably through the participation of the NPY Y1 receptors found in the lateral septal nuclei. |
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Authors:
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Miguel Molina-Hernández; N Patricia Téllez-Alcántara |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-28 |
Journal Detail:
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Title: Peptides Volume: - ISSN: 1873-5169 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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