Document Detail


Fluorous affinity chromatography for enrichment and determination of perfluoroalkyl substances.
MedLine Citation:
PMID:  22816675     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The adsorption behavior of four perfluoroalkyl acids, including the environmentally relevant perfluorooctanoic acid, has been investigated on a straight-chain perfluorohexyl adsorbent. The aim of this study was to probe the potential of perfluorinated materials for the analysis and enrichment of perfluoroalkyl analytes. Water-acetonitrile mixtures to which formic acid had been added (generally, 0.1\%) were employed as mobile phases. For all perfluorinated acids an U-shaped retention profile was observed by changing the amount of acetonitrile in mobile phase. This behavior has been correlated to the excess adsorption of the organic component on the adsorbent surface. The concept of perfluoromethylene selectivity has been defined as the ability of a chromatographic system to discriminate between molecules that differ by a single perfluoromethylene group. The contribution to the Gibbs free energy of phase transfer for the passage of a perfluoroalkyl carbon from the mobile to the stationary phase has been evaluated. This information, in addition to the traditional van't Hoff analysis, has been used also to estimate the analogous contribution but for the transfer of a carboxylic unit. Finally, insights into the retention mechanisms of perfluoroalkyl acids on straight-chain perfluorohexyl sorbents are discussed.
Authors:
Nicola Marchetti; Lorenzo Caciolli; Aldo Laganà; Francesco Gasparrini; Luisa Pasti; Francesco Dondi; Alberto Cavazzini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-19
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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